190520-92-4

Basic information

• Product Name: Thiophene, 2-bromo-3-[2-(2,4,6-trimethylphenyl)ethyl]-
• CAS NO: 190520-92-4
• Molecular Formula: C15H17BrS
• Molecular Weight: 309.27
• Mol File: 190520-92-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Thiophene, 2-bromo-3-[2-(2,4,6-trimethylphenyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophene, 2-bromo-3-[2-(2,4,6-trimethylphenyl)ethyl]-(190520-92-4)
• EPA Substance Registry System: Thiophene, 2-bromo-3-[2-(2,4,6-trimethylphenyl)ethyl]-(190520-92-4)

Safety Data

• Hazardous Substances Data: 190520-92-4(Hazardous Substances Data)

Upstream product

• 190520-89-9 3-[2-(2,4,6-Trimethyl-phenyl)-ethyl]-thiophene 
• 34846-44-1 3-Bromomethylthiophene 
• 21382-79-6 (thiophene-3-ylmethyl)phosphonic acid diethyl ester 
• 190520-84-4 3-[(E)-2-(2,4,6-Trimethyl-phenyl)-vinyl]-thiophene 

Downstream Products

• 190520-94-6 3-[2-(2,4,6-Trimethyl-phenyl)-ethyl]-thiophene-2-sulfonyl chloride 

Relevant articles and documents

Amide bond surrogates: A study in thiophenesulfonamide eased endothelin receptor antagonists

The potential proteolytic instability of the amide bond present in some ET(A) selective thiophenesulfonamide endothelin antagonists exemplified by TBC-10708 led us to investigate the replacement of this moiety with stable amide bond surrogates such as a trans double bond and an ethylene spacer. The effect of these replacements on the binding affinity is described.