34846-44-1Relevant academic research and scientific papers
Synthesis and characterization of block copolythiophene with hexyl and triethylene glycol side chains
Higashihara, Tomoya,Ohshimizu, Kaoru,Ryo, Yecheol,Sakurai, Takuya,Takahashi, Ayumi,Nojima, Shuichi,Ree, Moonhor,Ueda, Mitsuru
, p. 3687 - 3695 (2011)
A well-defined diblock copolythiophene, poly(3-hexylthiophene)-b-poly(3-(2- (2-(2-methoxyethoxy)ethoxy)ethoxy)methylthiophene) (P3HT-b-P3TEGT) was successfully synthesized by a Grignard metathesis (GRIM) polymerization. The structure of the block copolymer was confirmed by size exclusion chromatography (SEC), 1H NMR spectroscopy, differential scanning calorimetry (DSC), ultraviolet-visible (UV-vis) spectroscopy and fluorescence spectroscopy. The self-assembled structure of the block copolythiophene was investigated by atomic force microscopy (AFM), transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and synchrotron grazing incidence X-ray scattering (GIXS). These analyses found that the block components in films form vertically oriented lamellar structure via phase separation. Furthermore, both the phases were found to consist of molecular multi-layers respectively, in which the layers stack in the out-of-plane of the film. The P3HT phase exhibited crystalline, which is originated from the π-π stacked thiophene backbones. In contrast, the poly(3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)methylthiophene) (P3TEGT) phase revealed amorphous. Overall, the amphiphilic nature of P3HT-b-P3TEGT successfully demonstrated to lead to well-defined self-assembly structure in films.
Transient Photoconductivity of Acceptor-Substituted Poly(3-butylthiophene)
Greenwald, Y.,Cohen, G.,Poplawski, J.,Ehrenfreund, E.,Speiser, S.,Davidov, D.
, p. 2980 - 2984 (1996)
We have studied acceptor-substituted poly(3-butylthiophene) in an attempt to examine the role of acceptor moplecules as intrinsic charge traps under light excitations by measuring the transient photoconductivity response following pulse excitation.The specially synthesized acceptor molecule is a chemically prepared high electron affinity (HEA) monomer, (1-(4-nitrophenyl)-2-(3-thienyl)ethene.In the copolymers prepared with this acceptor monomer we have observed simultaneous decrease of the sub-nanosecond photoconductivity and increase of the slow component (t > 10 ns) photoconductivity, with increasing HEA group concentration in the substituted poly(butylthiophene)s.The slow component is attributed to a bimolecular recombination process.
Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors
Butts, Craig P.,Collingridge, Graham L.,Jane, David E.,Mallah, Shahida,Molnár, Elek,Re?nik, Lisa-Maria,Thatcher, Robert J.,Willis, Christine L.
supporting information, p. 9154 - 9162 (2021/11/16)
(-)-Arctigenin and a series of new analogues have been synthesised and then tested for their potential as AMPA and kainate receptor antagonists of human homomeric GluA1 and GluK2 receptors expressed in HEK293 cells using a Ca2+ influx assay. In general, these compounds showed antagonist activity at both receptors with greater activity evident at AMPARs. Schild analysis indicates that a spirocyclic analogue 6c acts as a non-competitive antagonist. Molecular docking studies in which 6c was docked into the X-ray crystal structure of the GluA2 tetramer suggest that (-)-arctigenin and its analogues bind in the transmembrane domain in a similar manner to the known AMPA receptor non-competitive antagonists GYKI53655 and the antiepileptic drug perampanel. The arctigenin derivatives described herein may serve as novel leads for the development of drugs for the treatment of epilepsy. This journal is
Preparation method 3- thiophene formaldehyde
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Paragraph 0044-0045; 0047-0048; 0050-0051; 0053-0054, (2020/03/23)
The preparation method disclosed by the invention has the advantages that 3 -methylmorpholine - N N-oxide, is mixed and heated to: DEG 3 - to keep the first temperature unchanged, after being kept at first temperature for a period of time and then filtered, to obtain N -halothiophene in a mild reaction condition . The method first comprises, DEG C and, hours after being, heated to 3 - DEG C and then filtering the mixture solution; of, halogenomethylthiophene to prepare 3 -thiophene formaldehyde pure product N - through cooling, and washing second to obtain crude,halothiophene by further rectification, and the preparation method disclosed by the invention is suitable for 3 - industrial production,thieno-formaldehyde, in a high-selectivity, high yield 3 - The present invention discloses 3 -desolvoked,methyl, thiophenecarboxaldehyde is obtained, by further distillation . The preparation method disclosed by the invention, is simple.
Opioid receptor agonists and application thereof
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Paragraph 1968; 1971-1975; 2008; 2012-2017, (2019/01/24)
The invention discloses compounds and salts thereof that can be used as opioid receptor ligands, a preparation method of the compounds, compositions containing the compounds, and a use of the compounds as [mu] opioid receptor agonists; the compounds are used for treatment of [mu] opioid receptor-mediated related diseases, such as pains and pain-related disorders.
Silver-Assisted Oxidative Isocyanide Insertion of Ethers: A Direct Approach to β-Carbonyl α-Iminonitriles
Zhao, Leiyang,Liu, Bingxin,Tan, Qitao,Ding, Chang-Hua,Xu, Bin
supporting information, p. 9223 - 9227 (2019/11/14)
An efficient silver-assisted oxidative coupling of simple ethers with tert-butyl isocyanide was realized in the presence of DDQ. The direct synthesis of high density functional β-carbonyl α-iminonitriles was achieved in a single step with high yields through the synergetic cascade isocyanide insertion into C(sp3)-H bond, where the isocyanide was used as crucial "CN" and "C=N" sources and the tert-butoxyl group acted as the carbonyl source. Diverse reactivity of β-carbonyl α-iminonitriles has been demonstrated.
A 2 - bromo - 3 - thiophene carboxylic acid intermediates of the synthesis method (by machine translation)
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Paragraph 0025-0029; 0043; 0044-0046, (2017/08/28)
The invention relates to 2 - bromo - 3 - thiophenecarboxylic acid synthesis method, comprises the following synthetic steps: 1): by 3 - methyl thiophene as raw materials, adding N - bromosuccinimide synthesis of 2 - bromo - 3 methyl thiophene; 2): by the 2 - bromo - 3 methyl thiophene to carbon tetrachloride as solvent, azobisisobutyronitrile as initiator with the N - bromosuccinimide synthesis of 2 - bromo - 3 - (bromomethyl) thiophene; 3): by the 2 - bromo - 3 - (bromomethyl) thiophene is 2 - iodo acyl benzoic acid oxidation to obtain 2 - bromo - 3 - thiophene formaldehyde; 4): by the 2 - bromo - 3 - thiophene formaldehyde sodium hydroxide aqueous solution as the solvent, is potassium permanganate oxidation to obtain 2 - bromo - 3 - thiophenecarboxylic acid. The invention has the advantages of: this invention uses the first to 2 of bit bromine substituted, then 3 of the oxidation of the synthetic route, mild reaction conditions, reactants are cheap and easily obtained, the yield is high. 2nd, greatly inhibit the double-bromo product, increasing the yield. (by machine translation)
Conjugated Thiophene-Fused Isatin Dyes through Intramolecular Direct Arylation
Nitti, Andrea,Signorile, Marco,Boiocchi, Massimo,Bianchi, Gabriele,Po, Riccardo,Pasini, Dario
, p. 11035 - 11042 (2016/11/29)
We report on the design, synthesis, and properties of innovative, planar, π-conjugated compounds in which a thiophene ring is fused with the skeleton of the naturally occurring dye isatin. The synthesis is achieved in high yields making use of an intramolecular direct arylation reaction as the key step, making the overall process potentially scalable. The synthetic sequence has been demonstrated also for an isatin bearing fluorine substituents on the aromatic ring. NMR and X-ray studies demonstrate the crosstalk occurring between the fused, coplanar, and conjugated moieties, making these novel dyes with a donor-acceptor character. Cyclic voltammetry and UV-vis studies confirm very interesting HOMO-LUMO levels and energy gaps for the new compounds.
Synthesis and characterization of new nematic liquid crystalline compounds-based thiophene units
Jia, Ying-Gang,Su, Dong,Guo, Zhi-Hao,Hu, Jian-She
, p. 91 - 102 (2016/02/19)
Four new liquid crystalline thiophene compounds (M1-M4) with a long flexible spacer were prepared. Their structures were characterized by Fourier transform infrared and proton nuclear magnetic resonance. The mesomorphism and thermal stability were investigated with differential scanning calorimetry, polarizing optical microscopy, and thermogravimetric analysis. The photo-physical properties were evaluated using ultraviolet/visible spectroscopy and photoluminescence. M1-M4 all showed thermotropic mesogenic properties with excellent thermal stability, and exhibited nematic threaded texture, droplet texture, and Schlieren texture on heating and cooling cycles. The effect of flexible spacer and terminal groups on mesomorphic and spectroscopic property is discussed. The experimental results demonstrated that the tendency toward melting temperature (Tm) decreased, while isotropic temperature (Ti) increased with increasing the flexible spacer length. In CHCl3 solution, these thiophene compounds displayed an intense broad absorption band peaking within 230-340 nm and a maximum fluorescent emission wavelength at 426-439 nm.
Asymmetric Dearomatization of 1-Aminonaphthalene Derivatives through C-C Bond Formation with Electron-Rich Heterocycles as Nucleophiles
Baba, Takafumi,Oka, Junko,Noguchi, Keiichi,Tanaka, Ken
, p. 4374 - 4382 (2015/07/27)
A cationic gold(I)/axially chiral biaryl bis(phosphine) complex has been employed to catalyze the asymmetric dearomatization reactions of 1-aminonaphthalene derivatives through a C-C bond-forming reaction with electron-rich heterocycles as the nucleophiles. These reactions afford pentacyclic heterocycles in good yields with moderate enantiomeric excess (ee) values. A cationic gold(I)/axially chiral biaryl bis(phosphine) complex has been employed to catalyze the asymmetric dearomatization of 1-aminonaphthalene derivatives through a C-C bond-forming reaction with electron-rich heterocycles as the nucleophiles. These reactions afford pentacyclic heterocycles in good yields with moderate enantiomeric excess (ee) values.
