34846-44-1Relevant articles and documents
Synthesis and characterization of block copolythiophene with hexyl and triethylene glycol side chains
Higashihara, Tomoya,Ohshimizu, Kaoru,Ryo, Yecheol,Sakurai, Takuya,Takahashi, Ayumi,Nojima, Shuichi,Ree, Moonhor,Ueda, Mitsuru
, p. 3687 - 3695 (2011)
A well-defined diblock copolythiophene, poly(3-hexylthiophene)-b-poly(3-(2- (2-(2-methoxyethoxy)ethoxy)ethoxy)methylthiophene) (P3HT-b-P3TEGT) was successfully synthesized by a Grignard metathesis (GRIM) polymerization. The structure of the block copolymer was confirmed by size exclusion chromatography (SEC), 1H NMR spectroscopy, differential scanning calorimetry (DSC), ultraviolet-visible (UV-vis) spectroscopy and fluorescence spectroscopy. The self-assembled structure of the block copolythiophene was investigated by atomic force microscopy (AFM), transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and synchrotron grazing incidence X-ray scattering (GIXS). These analyses found that the block components in films form vertically oriented lamellar structure via phase separation. Furthermore, both the phases were found to consist of molecular multi-layers respectively, in which the layers stack in the out-of-plane of the film. The P3HT phase exhibited crystalline, which is originated from the π-π stacked thiophene backbones. In contrast, the poly(3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)methylthiophene) (P3TEGT) phase revealed amorphous. Overall, the amphiphilic nature of P3HT-b-P3TEGT successfully demonstrated to lead to well-defined self-assembly structure in films.
Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors
Butts, Craig P.,Collingridge, Graham L.,Jane, David E.,Mallah, Shahida,Molnár, Elek,Re?nik, Lisa-Maria,Thatcher, Robert J.,Willis, Christine L.
supporting information, p. 9154 - 9162 (2021/11/16)
(-)-Arctigenin and a series of new analogues have been synthesised and then tested for their potential as AMPA and kainate receptor antagonists of human homomeric GluA1 and GluK2 receptors expressed in HEK293 cells using a Ca2+ influx assay. In general, these compounds showed antagonist activity at both receptors with greater activity evident at AMPARs. Schild analysis indicates that a spirocyclic analogue 6c acts as a non-competitive antagonist. Molecular docking studies in which 6c was docked into the X-ray crystal structure of the GluA2 tetramer suggest that (-)-arctigenin and its analogues bind in the transmembrane domain in a similar manner to the known AMPA receptor non-competitive antagonists GYKI53655 and the antiepileptic drug perampanel. The arctigenin derivatives described herein may serve as novel leads for the development of drugs for the treatment of epilepsy. This journal is
Opioid receptor agonists and application thereof
-
Paragraph 1968; 1971-1975; 2008; 2012-2017, (2019/01/24)
The invention discloses compounds and salts thereof that can be used as opioid receptor ligands, a preparation method of the compounds, compositions containing the compounds, and a use of the compounds as [mu] opioid receptor agonists; the compounds are used for treatment of [mu] opioid receptor-mediated related diseases, such as pains and pain-related disorders.
A 2 - bromo - 3 - thiophene carboxylic acid intermediates of the synthesis method (by machine translation)
-
Paragraph 0025-0029; 0043; 0044-0046, (2017/08/28)
The invention relates to 2 - bromo - 3 - thiophenecarboxylic acid synthesis method, comprises the following synthetic steps: 1): by 3 - methyl thiophene as raw materials, adding N - bromosuccinimide synthesis of 2 - bromo - 3 methyl thiophene; 2): by the 2 - bromo - 3 methyl thiophene to carbon tetrachloride as solvent, azobisisobutyronitrile as initiator with the N - bromosuccinimide synthesis of 2 - bromo - 3 - (bromomethyl) thiophene; 3): by the 2 - bromo - 3 - (bromomethyl) thiophene is 2 - iodo acyl benzoic acid oxidation to obtain 2 - bromo - 3 - thiophene formaldehyde; 4): by the 2 - bromo - 3 - thiophene formaldehyde sodium hydroxide aqueous solution as the solvent, is potassium permanganate oxidation to obtain 2 - bromo - 3 - thiophenecarboxylic acid. The invention has the advantages of: this invention uses the first to 2 of bit bromine substituted, then 3 of the oxidation of the synthetic route, mild reaction conditions, reactants are cheap and easily obtained, the yield is high. 2nd, greatly inhibit the double-bromo product, increasing the yield. (by machine translation)
