190585-65-0

Upstream product

• 20443-98-5 2,6-Dichlorobenzyl bromide 
• 190523-00-3 3,4-dihydroxy-5,2'-dinitrobenzophenone 
• 190522-94-2 4-benzyloxy-3-methoxy-2'-nitro benzhydrol 
• 190522-96-4 4-benzyloxy-3-methoxy-2'-nitro benzophenone 
• 190522-98-6 4-hydroxy-3-methoxy-5,2'-dinitro benzophenone 
• 190522-97-5 4-hydroxy-3-methoxy-2'-nitro benzophenone 
• 577-19-5 2-nitrophenyl bromide 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 

Relevant academic research and scientific papers

Synthesis of [18F]Ro41-0960, a potent catechol-O-methyltransferase inhibitor, for PET studies

Ro41-0960 (3,4-dihydroxy-5-nitro-2'-fluorobenzophenone is a potent, fluorine containing COMT inhibitor. In order to map catechol-O-methyltransferase (COMT) in vivo with PET, no-carrier-added [18F]Ro41-0960 was synthesized by the nucleophilic aromatic substitution of [18F]fluoride for 2'-nitro on 3,4-dimethoxy-5,2'-dinitrobenzophenone, followed by hydrolysis with HBr. During the course of this study it was found that [18F]fluoromethane ([18F]CH3F) was generated as the side product of nucleophilic aromatic substitution reaction. Various precursors with different hydroxyl protecting groups were then investigated for the effects on this side reaction.