19059-68-8

Usage

Uses

Used in Personal Care Products:
3-DIMETHYLAMINO-2,2-DIMETHYL-1-PROPANOL is used as a pH adjuster, emulsifier, and conditioning agent in personal care products such as skin care, hair care, and cosmetics. It is known for its anti-aging properties, improving skin firmness, hydration, and texture.
Used in Pharmaceutical Synthesis:
3-DIMETHYLAMINO-2,2-DIMETHYL-1-PROPANOL is used as a catalyst in the synthesis of pharmaceuticals, contributing to the development of new medications.
Used in Polyurethane Foam Production:
3-DIMETHYLAMINO-2,2-DIMETHYL-1-PROPANOL is used as a catalyst in the preparation of polyurethane foams, enhancing the production process and resulting in improved foam properties.
Safety Precautions:
While 3-DIMETHYLAMINO-2,2-DIMETHYL-1-PROPANOL offers numerous benefits, it should be handled with caution due to its potential as a skin and eye irritant. Inhalation may also cause respiratory irritation, necessitating proper safety measures during its use.

Upstream product

• 15451-14-6 3-dimethylamino-2,2-dimethylpropanal 
• 40894-00-6 3-bromo-2,2-dimethyl-propan-1-ol 
• 124-40-3 dimethyl amine 
• 114380-14-2 Trimethyl-<3-hydroxy-2.2-dimethyl-propyl>-ammoniumhydroxyd 
• 21678-37-5 N,N,2-trimethylpropionamide 

Downstream Products

• 109469-21-8 4-isobutoxy-benzoic acid-(3-dimethylamino-2,2-dimethyl-propyl ester) 
• 114619-31-7 2,4-bis-(3-dimethylamino-2,2-dimethyl-propoxymethyl)-1-methoxy-benzene 
• 39943-25-4 4-nitro-benzoic acid-(3-dimethylamino-2,2-dimethyl-propyl ester) 
• 109469-13-8 4-butoxy-benzoic acid-(3-dimethylamino-2,2-dimethyl-propyl ester) 
• 39943-07-2 benzilic acid-(3-dimethylamino-2,2-dimethyl-propyl ester) 
• 901308-39-2 C₃₇H₄₅F₃N₄O₄S 
• 870545-65-6 C₂₉H₃₇FN₄O₃ 

Relevant academic research and scientific papers

METHOD FOR SYNTHESIZING AMINOALCOHOLS

The present invention relates to a method for synthesizing amonoalcohols (e.g., aminoalcohols that contain an amine group that is either unsubstituted, mono-substituted, or di-substituted) and to the products formed therefrom. In one embodiment, the present invention relates to a method for synthesizing aminoalcohols from a corresponding aminoaldehyde and to the products formed therefrom. In another embodiment, the present invention relates to a method for synthesizing aminoalcohols from a corresponding aminoaldehyde via a hydrogenation process using a suitable catalyst (e.g., Raney Nickel) and to the products formed therefrom. In still another embodiment, the present invention relates to aminoalcohols formed via direct hydrogenation from a corresponding aminoaldehyde without the intervening step of converting the aminoaldehyde starting material to a salt.

Mechanism of esterification of 1,3-dimethylamino alcohols by N-acetylimidazole in acetonitrile and the influence of alkyl and geminal dialkyl substitution upon the rate

3-(Dimethylamino)propan-1-ol and seven derivatives with alkyl substituents at the 2-position have been prepared by conventional methods, and second-order rate constants for their esterification by N-acetylimidazole in acetonitrile have been measured under pseudo-first-order conditions both by 1H NMR spectroscopy at a single temperature (23°C) and by a UV spectroscopic method over the temperature range 25-65°C. Evidence is presented that the intermolecular esterifications proceed via an initial rate-determining intramolecular general base catalysed formation of a cyclic tetrahedral intermediate. Effective molarities compared with the third-order reactions of simpler alcohols with acetylimidazole catalysed by triethylamine are estimated to be 13-14 mol dm-3, but alkyl substitution at the 2-position of the amino alcohol has only a modest effect upon reaction rates. All reactions have substantial negative entropies of activation and only modest enthalpies of activation as expected for concerted bimolecular reactions with highly ordered transition structures. Three structurally related carbocyclic amino alcohols constitute a short isokinetic series with the isokinetic temperature very close to the experimental range. Along this series, decreasing enthalpies of activation are almost exactly balanced in their contributions to the overall free energy of activation near room temperature by increasingly negative entropies of activation.