190654-85-4Relevant academic research and scientific papers
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2
Vicenti, Ilaria,Martina, Maria Grazia,Boccuto, Adele,De Angelis, Marta,Giavarini, Giorgia,Dragoni, Filippo,Marchi, Serena,Trombetta, Claudia Maria,Crespan, Emmanuele,Maga, Giovanni,Eydoux, Cecilia,Decroly, Etienne,Montomoli, Emanuele,Nencioni, Lucia,Zazzi, Maurizio,Radi, Marco
, (2021)
The worldwide circulation of different viruses coupled with the increased frequency and diversity of new outbreaks, strongly highlight the need for new antiviral drugs to quickly react against potential pandemic pathogens. Broad-spectrum antiviral agents
2,6,9-Trisubstituted purines: Optimization towards highly potent and selective CDK1 inhibitors
Imbach, Patricia,Capraro, Hans-Georg,Furet, Pascal,Mett, Helmut,Meyer, Thomas,Zimmermann, Juerg
, p. 91 - 96 (2007/10/03)
Novel 2,6,9-substituted purine derivatives represent a class of potent and selective inhibitors of CDK1/cyclinB. The synthesis, SAR and biological profile of selected compounds are described.
