190662-30-7

Basic information

• Product Name: (17α)-3,3-[1,2-Ethanediylbis(oxy)]-17-hydroxy-19-norpregna-5(10),9(11)-diene-21-nitrile
• Synonyms: (17α)-3,3-[1,2-Ethanediylbis(oxy)]-17-hydroxy-19-norpregna-5(10),9(11)-diene-21-nitrile;(17alpha)-3,3-[1,2-Ethanediylbis(oxy)]-17-hydroxy-19-norpregna-5(10),9(11)-diene-21-nitrile;2-[(8S,13S,14S,17R)-17-hydroxy-13-methylspiro[1,2,4,6,7,8,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,2'-1,3-dioxolane]-17-yl]acetonitrile
• CAS NO: 190662-30-7
• Molecular Formula: C22H29NO3
• Molecular Weight: 355.47056
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 190662-30-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 565.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• PKA: 13.62±0.40(Predicted)
• CAS DataBase Reference: (17α)-3,3-[1,2-Ethanediylbis(oxy)]-17-hydroxy-19-norpregna-5(10),9(11)-diene-21-nitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (17α)-3,3-[1,2-Ethanediylbis(oxy)]-17-hydroxy-19-norpregna-5(10),9(11)-diene-21-nitrile(190662-30-7)
• EPA Substance Registry System: (17α)-3,3-[1,2-Ethanediylbis(oxy)]-17-hydroxy-19-norpregna-5(10),9(11)-diene-21-nitrile(190662-30-7)

Safety Data

• Hazardous Substances Data: 190662-30-7(Hazardous Substances Data)

Usage

Uses

(17α)-3,3-[1,2-Ethanediylbis(oxy)]-17-hydroxy-19-norpregna-5(10),9(11)-diene-21-nitrile is an intermediate of Dienogest (D441870), a derivative of 19-Nortestosterone (N315000) and an oral contraceptive used in combination with estrogen.

Upstream product

• 5571-36-8 ethylene deltenone 
• 75-05-8 acetonitrile 

Downstream Products

• 106111-42-6 17α-Cyanomethyl-17β-hydroxy-estra-5(10),9(11)-dien-3-on 
• 65928-58-7 Dienogest 

Relevant articles and documents

Preparation method of dienogest

The invention relates to a preparation method of dienogest. The preparation method comprises the following steps: providing a compound with a structure shown as a formula (II); and carrying out an acidolysis deprotection reaction on the compound shown in the formula (II) in an aqueous fluoboric acid solution to prepare a compound with a structure shown in a formula (I). According to the preparation method of the dienogest, the problems of low purity and dark color of a crude product of an acidolysis deprotection process are fundamentally solved, a production process is greatly simplified, andthe production cost of an enterprise is reduced.

Method for the preparation of steroid derivative ketal

The invention relates to a method for the preparation of a compound of formula II: STR1 wherein a compound of formula V: STR2 is condensed with a compound of the formula CH3 -C(OR4 O)-(CH2)3 -XHal and R1, R2, R3, R4, X and Hal are as defined by the specification.