19069-63-7

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-3-PHENYLPYRIDINE is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into various drug molecules, contributing to their therapeutic properties.
Used in Agrochemical Industry:
4-CHLORO-3-PHENYLPYRIDINE is used as an intermediate in the synthesis of agrochemicals for its potential to be part of compounds that can be used in crop protection and pest control.
Used in Organic Compounds Production:
4-CHLORO-3-PHENYLPYRIDINE is used as a building block in the production of various heterocyclic compounds, which are important in the creation of complex organic molecules with diverse applications.
Safety Precautions:
4-CHLORO-3-PHENYLPYRIDINE is considered to be potentially hazardous, and proper safety precautions should be taken when handling and storing this chemical to ensure the well-being of individuals and the environment.

InChI:InChI=1/C11H8ClN/c12-11-6-7-13-8-10(11)9-4-2-1-3-5-9/h1-8H

Upstream product

• 1131-48-2 3-phenylpyridine N-oxide 
• 36953-42-1 3-bromo-4-chloropyridine 
• 98-80-6 phenylboronic acid 
• 1211524-38-7 4-amino-3-phenylpyridine 
• 19798-77-7 4-amino-3-chloropyridine 
• 7379-35-3 4-chlorpyridine hydrochloride 

Downstream Products

• 417721-24-5 4-(3-phenylpyridin-4-yl)oxyaniline 
• 417724-79-9 4-(4-nitrophenoxy)-3-phenylpyridine 
• 1404219-22-2 C₁₇H₁₂Cl₂N₂OS₂ 

Relevant academic research and scientific papers

Selective Halogenation of Pyridines Using Designed Phosphine Reagents

Halopyridines are key building blocks for synthesizing pharmaceuticals, agrochemicals, and ligands for metal complexes, but strategies to selectively halogenate pyridine C-H precursors are lacking. We designed a set of heterocyclic phosphines that are installed at the 4-position of pyridines as phosphonium salts and then displaced with halide nucleophiles. A broad range of unactivated pyridines can be halogenated, and the method is viable for late-stage halogenation of complex pharmaceuticals. Computational studies indicate that C-halogen bond formation occurs via an SNAr pathway, and phosphine elimination is the rate-determining step. Steric interactions during C-P bond cleavage account for differences in reactivity between 2- and 3-substituted pyridines.

ARYL TRIAZINE COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT USING THE SAME

PROBLEM TO BE SOLVED: To provide an electron transporting material that achieves excellent life characteristics and current efficiency in an organic electroluminescent element. SOLUTION: A triazine compound represented by formula (1) is provided. In the f

SHMT INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Scope and limitation for FeSO4-mediated direct arylation of heteroarenes with arylboronic acids and its synthetic applications

FeSO4-mediated direct arylation of heteroarenes with arylboronic acids in the presence of K2S2O8 has been developed. A slow addition of an aqueous solution of an iron complex was crucial in the arylation. Scope and limitation of the heteroarenes and arylboronic acids are discussed. Furthermore, the direct arylation was applied to the formal total synthesis botryllazine B and sodium channel inhibitor.

Site-Selectivity in the Reaction of 3-Substituted Pyridine 1-Oxides with Phosphoryl Chloride

Site-selectivity in the reaction of 3-substituted pyridine 1-oxide with phosphoryl chloride was investigated.When a strongly electron-withdrawing group (e.g.CN, CONRR', COOR, or NO2) was substituted at the 3-position, the reaction of 3-substituted pyridine 1-oxides with phosphoryl chloride yielded 3-substituted 2-chloropyridines as the main products.Keywords- site-selectivity; 3-substituted pyridine 1-oxide; phosphoryl chloride; 3-substituted 2-chloropyridine; chlorination