1131-48-2

Basic information

• Product Name: Pyridine, 3-phenyl-, 1-oxide
• CAS NO: 1131-48-2
• Molecular Formula: C11H9NO
• Molecular Weight: 171.199
• Mol File: 1131-48-2.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Pyridine, 3-phenyl-, 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-phenyl-, 1-oxide(1131-48-2)
• EPA Substance Registry System: Pyridine, 3-phenyl-, 1-oxide(1131-48-2)

Safety Data

• Hazardous Substances Data: 1131-48-2(Hazardous Substances Data)

Usage

General Description

Pyridine, 3-phenyl-, 1-oxide, also known as 3-Phenylpyridine N-oxide, is an organic compound with the chemical formula C11H9NO. It consists of a pyridine ring with a phenyl group attached at the 3-position and an oxygen atom in the 1-position. This chemical is commonly used as a reagent in organic synthesis and as a precursor for various pharmaceuticals. It is also known for its use in the synthesis of certain dyes and as a stabilizer for certain polymers. Additionally, 3-Phenylpyridine N-oxide has been investigated for its potential antioxidant and neuroprotective properties. However, it is important to handle this chemical with caution as it can be harmful if inhaled, ingested, or in contact with skin.

Upstream product

• 1008-88-4 3-phenylpyridine 
• 2402-97-3 3-bromopyridine N-oxide 
• 98-80-6 phenylboronic acid 

Downstream Products

• 76053-45-7 5-Phenyl-2(1H)-pyridinone 
• 136887-33-7 3-(1-adamantylthio)-5-phenylpyridine 
• 136887-32-6 2-(1-adamantylthio)-5-phenylpyridine 
• 136887-31-5 2-(1-adamantylthio)-3-phenylpyridine 
• 136887-34-8 Acetic acid (2S,3R,4S)-4-acetoxy-1-acetyl-2-(adamantan-1-ylsulfanyl)-5-phenyl-1,2,3,4-tetrahydro-pyridin-3-yl ester 
• 39065-45-7 2-cyano-5-phenylpyridine 
• 39065-43-5 3-phenylpicolinonitrile 
• 136887-35-9 Acetic acid (2R,3S,6S)-6-acetoxy-1-acetyl-2-(adamantan-1-ylsulfanyl)-5-phenyl-1,2,3,6-tetrahydro-pyridin-3-yl ester 
• 136887-36-0 1-[(2R,3S,4R)-3-(Adamantan-1-ylsulfanyl)-2,4-dihydroxy-5-phenyl-3,4-dihydro-2H-pyridin-1-yl]-ethanone 
• 66600-05-3 2-chloro-5-phenylpyridine 
• 31557-57-0 2-chloro-3-phenyl-pyridine 
• 19069-63-7 4-chloro-3-phenylpyridine 
• 928822-80-4 2-fluoro-5-phenyl-pyridine 
• 104813-87-8 1-(3-phenyl-2-pyridinyl)piperazine 

Relevant articles and documents

Investigation on Factors Ruling Catalytic Efficiency and Chemical Stability of Mn(III) Porphyrins in HOCl Olefin Epoxidation: Conditions for Practical Applications

The use of stable Mn(III) porphyrins (P), e.g. 2-4, and of imidazole or pyridine axial ligands (L), 8-10, entirely soluble in the organic phase has allowed an extensive investigation of the factors ruling the catalytic activity of porphyrins in the olefin

An efficient Pd(II)-(2-aminonicotinaldehyde) complex as complementary catalyst for the Suzuki-Miyaura coupling in water

An efficient new Pd(II)-(2-aminonicotinaldehyde)-catalyzed Suzuki-Miyaura coupling of the aryl halides (Br, Cl and I) and organoboronic acids at moderate temperature in water is described. Low catalyst loading, easy accessibility, being an air-stable catalyst, functional group compatibility, and water as the reaction medium are some of the key features of this synthetic method. This protocol is also applicable for gram scale.

2,2′-Homocoupled Azine N,N′-Dioxides or Azine N-Oxides: CDC- or SNAr-Controlled Chemoselectivity

An unprecedented Cu(OAc)2- and LiOtBu-mediated homocoupling of azine N-oxides to yield 2,2′-azine N,N′-dioxides is reported. This is the first instance in which copper has been used to catalyze the homodimerization reaction, especially of 2-phenylpyridine N-oxides. In the absence of catalytic copper, the reaction follows an alternative pathway, and instead of dioxides it yields 2,2′-azine N-monoxides. This latter protocol works efficiently with a range of N-heterocyclic oxides of pyridine, 2-phenylpyridine, quinoline and N-aryl-1,2,3-triazole. It is scalable, offers high regioselectivity and gives the products in moderate to high yields. The observed chemoselectivity between the copper-assisted and copper-free protocols is routed through oxidative cross-dehydrogenative coupling (CDC) and nucleophilic aromatic substitution of hydrogen (SNAr) pathways, respectively.