19070-95-2

Usage

Chemical composition

Consists of a biphenyl group linked to an ethyl group via an oxygen atom.

Physical state

A clear, colorless liquid.

Uses

Primarily used as a solvent and as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Also used in the production of fragrances, flavors, and polymer stabilizers, as well as in the manufacturing of agricultural chemicals, dyes, and surfactants.

Safety

Considered to be relatively safe and stable when handled and stored properly, but should be used with caution and in accordance with safety guidelines due to its potential flammability and toxicity.

Upstream product

• 54334-74-6 ethyl 2-(biphenyl-4-yloxy)acetate 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 107-21-1 ethylene glycol 
• 126301-69-7 2-(4-phenylphenoxy)-ethyl-tetrahydropyranyl-ether 
• 92-69-3 4-Phenylphenol 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 103594-20-3 8-Methoxy-8-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-diene 
• 92-69-3 4-Phenylphenol 
• 103097-49-0 1-(2-biphenyl-4-yloxy-ethyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Inhibition of group IVA cytosolic phospholipase A2by thiazolyl ketones in vitro, ex vivo, and in vivo

Group IVA cytosolic phospholipase A2(GIVA cPLA2) is the rate-limiting provider of pro-inflammatory mediators in many tissues and is thus an attractive target for the development of novel anti-inflammatory agents. In this work, we present the synthesis of new thiazolyl ketones and the study of their activities in vitro, in cells, and in vivo. Within this series of compounds, methyl 2-(2-(4-octylphenoxy)acetyl)thiazole-4-carboxylate (GK470) was found to be the most potent inhibitor of GIVA cPLA2, exhibiting an XI(50) value of 0.011 mole fraction in a mixed micelle assay and an IC50of 300 nM in a vesicle assay. In a cellular assay using SW982 fibroblast-like synoviocytes, it suppressed the release of arachidonic acid with an IC50value of 0.6 μM. In a prophylactic collagen-induced arthritis model, it exhibited an anti-inflammatory effect comparable to the reference drug methotrexate, whereas in a therapeutic model, it showed results comparable to those of the reference drug Enbrel. In both models, it significantly reduced plasma PGE2levels.

Copper(ii)-catalyzed C-O coupling of aryl bromides with aliphatic diols: Synthesis of ethers, phenols, and benzo-fused cyclic ethers

A highly efficient copper-catalyzed C-O cross-coupling reaction between aryl bromides and aliphatic diols has been developed employing a cheaper, more efficient, and easily removable copper(ii) catalyst. A broad range of aryl bromides were coupled with aliphatic diols of different lengths using 5 mol% CuCl2 and 3 equivalents of K2CO3 in the absence of any other ligands or solvents to afford the corresponding hydroxyalkyl aryl ethers in good to excellent yields. In this newly developed protocol, aliphatic diols have multilateral functions as coupling reactants, ligands, and solvents. The resulting hydroxyalkyl aryl ethers were further readily converted into the corresponding phenols, presenting a valuable alternative way to phenols from aryl bromides. Furthermore, it was demonstrated that they are useful intermediates for more advanced molecules such as benzofurans and benzo-fused cyclic ethers. This journal is

ANTIINFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS

A compound of formula (I) wherein X is O, C O or S; Y is N or CH; R2 and R4 are each independently H, -(CH2)pCOOH, -(CH2)pCON(R5)2 or - (CH2)pCOOC 1-6alkyI; or R2 and R4 together form a 6-membered phenyl ring fused to the five membered ring; each R1 is independently selected from H, halo (e.g. fluoro or chloro), C6-10aryl, C7-12arylalkyl, C2-12alkenyl; OC1-2 alkyl, OC2-12 aikenyl or a C1-12 alkyl group; each R5 is H or C1-6 alkyl; each p is 0 to 3; n is 1 to 4; or a salt, ester, solvate, N-oxide, or prodrug thereof, e.g. a salt thereof.

Alkoxycarbonylamino benzoic acid or alkoxycarbonylamino tetrazolyl phenyl derivatives as IP antagonists

This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein G1 is selected from the group consisting of a, b1, and b2 and A and G2 are as defin

Cleavage of acetals promoted by copper (II) sulphate adsorbed on silica gel

Copper sulphate supported on silica gel promotes the easy removal of cyclic acetals and tetrahydropyranyl ethers to give the respective parent carbonyl and hydroxyl compounds.

Synthesis and Activity of Juvenile Hormone Analogues (JHA), Part II

Several derivatives of 4-phenoxyphenoxy-ethyl and 4-phenoxyphenylethyl bearing carbonate and thiolcarbonate as functional groups were synthesized.The products were tested for their respective juvenile hormone activity for Triatoma infestans.None of them showed an activity comparable to that of Fenoxycarb which was used as the standard control.The synthetic procedures and the biological results are discussed.Keywords: Juvenile Hormone Analogues, Activity, Synthesis