190727-08-3

Basic information

• Product Name: N-(3-Ethoxycarbonylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea
• Synonyms: N-(3-Ethoxycarbonylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea
• CAS NO: 190727-08-3
• Molecular Weight: 487.512
• Mol File: 190727-08-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-Ethoxycarbonylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Ethoxycarbonylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea(190727-08-3)
• EPA Substance Registry System: N-(3-Ethoxycarbonylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea(190727-08-3)

Safety Data

• Hazardous Substances Data: 190727-08-3(Hazardous Substances Data)

Upstream product

• 582-33-2 3-aminobenzoic acid ethyl ester 
• 190728-25-7 4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 144-55-8 sodium hydrogencarbonate 
• 67531-68-4 ethyl 3-isocyanatobenzoate 

Relevant articles and documents

Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same

The present invention relates to novel quinoline derivatives and quinazoline derivatives represented by the following formula (I): STR1 [wherein R 1 and R 2 are each independently H or C 1 -C 4 -alkyl, or R 1 and R 2 together form C 1 -C 3 -alkylene, X is O, S or CH 2, W is CH or N, and Q is a substituted aryl group or substituted heteroaryl group] and their pharmaceutically acceptable salts, having platelet-derived growth factor receptor autophosphorylation inhibitory activity, to pharmaceutical compositions containing these compounds, and to methods for the treatment of diseases associated with abnormal cell growth such as tumors.