19077-61-3

Basic information

• Product Name: 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid
• Synonyms: 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid
• CAS NO: 19077-61-3
• Molecular Formula: C₁₂H₉NO₄
• Molecular Weight: 231.2042
• Mol File: 19077-61-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 380.1°Cat760mmHg
• Flash Point: 183.7°C
• Appearance: /
• Density: 1.375g/cm³
• Vapor Pressure: 5.59E-06mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid(19077-61-3)
• EPA Substance Registry System: 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid(19077-61-3)

Safety Data

• Hazardous Substances Data: 19077-61-3(Hazardous Substances Data)

Usage

General Description

2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid, also known as 2-(2,5-dioxopyrrolidin-1-yl)benzoic acid, is a chemical compound with the molecular formula C12H7NO4. It is a pyrrolidine derivative that contains a benzoic acid moiety. 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid has been studied for its potential biological activities, including anti-inflammatory and antitumor properties. It has been used in research focusing on drug discovery and development, particularly in the field of medicinal chemistry. The compound's chemical structure and properties make it a promising candidate for further investigation in the pursuit of new pharmaceutical agents.

InChI:InChI=1/C12H9NO4/c1-17-12(16)8-4-2-3-5-9(8)13-10(14)6-7-11(13)15/h2-7H,1H3

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 112881-73-9 2-((Z)-3-Carboxy-acryloylamino)-benzoic acid methyl ester 
• 108-31-6 maleic anhydride 

Downstream Products

• 1229020-29-4 C₁₆H₁₅N₃O₆ 
• 1229020-48-7 C₃₁H₄₅N₃O₅ 

Relevant articles and documents

Design, synthesis and biochemical evaluation of novel ethanoanthracenes and related compounds to target burkitt’s lymphoma

Lymphomas (cancers of the lymphatic system) account for 12% of malignant diseases worldwide. Burkitt’s lymphoma (BL) is a rare form of non-Hodgkin’s lymphoma in which the cancer starts in the immune B-cells. We report the synthesis and preliminary studies on the antiproliferative activity of a library of 9,10-dihydro-9,10-ethanoanthracene based compounds structurally related to the antidepressant drug maprotiline against BL cell lines MUTU-1 and DG- 75. Structural modifications were achieved by Diels-Alder reaction of the core 9-(2- nitrovinyl)anthracene with number of dienophiles including maleic anhydride, maleimides, acrylonitrile and benzyne. The antiproliferative activity of these compounds was evaluated in BL cell lines EBV? MUTU-1 and EBV+ DG-75 (chemoresistant). The most potent compounds 13j, 15, 16a, 16b, 16c, 16d and 19a displayed IC50 values in the range 0.17–0.38 μM against the BL cell line EBV? MUTU-1 and IC50 values in the range 0.45–0.78 μM against the chemoresistant BL cell line EBV+ DG- 75. Compounds 15, 16b and 16c demonstrated potent ROS dependent apoptotic effects on the BL cell lines which were superior to the control drug taxol and showed minimal cytotoxicity to peripheral blood mononuclear cells (PBMCs). The results suggest that this class of compounds merits further investigation as antiproliferative agents for BL.

Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B

Structural optimization and preliminary structure-activity relationship studies of a series of N-substituted maleimide fused-pyrazole analogues with Cdc25B inhibitory activity, starting from a high-throughput screening hit, are illustrated. A simplified 3,5-diacyl pyrazole analogue was obtained as the most potent compound (118, IC50 = 0.12 μM) with a 270-fold increase in potency.

Ring Closure Reactions of ortho-Carboxymaleanilic Acids Revision of Structural Assignment

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