190781-52-3

Upstream product

• 162708-82-9 3,3,9-trimethyl-8-phenylthiomethyl-1,5-dioxaspiro<5.5>undec-8-ene 
• 162708-80-7 methyl 9-hydroxy-3,3-dimethyl-1,5-dioxaspiro<5.5>undec-8-en-8-carboxylate 
• 162708-81-8 methyl 3,3,9-trimethyl-1,5-dioxaspiro<5.5>undec-8-en-8-carboxylate 
• 190781-51-2 8-hydroxymethyl-3,3,9-trimethyl-1,5-dioxaspiro<5.5>undec-8-ene 
• 2973-86-6 lithium thiophenoxide 

Downstream Products

• 162708-83-0 2,2,4-trimethyl-3-phenylthiomethyl-cyclohex-3-en-1-one 

Relevant academic research and scientific papers

Synthesis of the taxol AB-system by olefination of an A-ring C1 ketone and direct B-ring closure

Two syntheses of 13-deoxy-taxol C1 ketones are presented. Olefination of these C1 ketones is achieved, indirectly, via either the Meyer-Schuster reaction or by introduction of a vinyl group with vinylcerium dichloride followed by allylic rearrangement. Bo

Synthesis of a Highly Functionalised AB Taxane Ring System: Formation of the Eight-membered Ring by an Efficient 8-exo-tet Alkylation of an α-Sulfonyl Anion

An efficient, scalable route to a Taxol A ring synthon has been developed; its successful elaboration to a highly functionalized AB system by means of a novel nucleophilic ring closure is described.