190782-97-9Relevant academic research and scientific papers
Preparation of 2-oxazolidinones by intramolecular nucleophilic substitution
Van Delft, Floris L.,Timmers, Cornelis M.,Van Der Marel, Gijs A.,Van Boom, Jacques H.
, p. 450 - 454 (2007/10/03)
Treatment of N-alkoxycarbonyl, N-benzyl protected β-amino alcohols with triphenylphosphine and hexachloroethane in 1,2-dichloroethane induces cyclization to 2-oxazolidinones, which are formed by intramolecular attack with inversion of configuration at the secondary alcohol. In contrast, mono N-substituted alkyl carbamates undergo chlorination under the same conditions.
