190788-29-5Relevant academic research and scientific papers
Microwave assisted synthesis of 5-methyl-1,3,4-thiadiazol-2-ylthio/tetrazol-1-yl substituted pyrazoles, 2-azetidmones, 4-thiazolidinones, benzopyran-2-ones and 1,3,4-oxadiazoles
Kidwai, Mazaahir,Kumar, Parven,Goel, Yogesh,Kumar, Kaushalendra
, p. 175 - 179 (2007/10/03)
The reaction of substituted aromatic aldehydes/ketones with 5-methyl-1,3,4-thiadiazol-2-ylthio/tetrazol-1-ylacetic acid hydrazides (1a-b) afford corresponding hydrazones (2a-b-7a-b). The hydrazones (2a-b, 3a-b) on treatment with DMF/POCl3 under microwave irradiation (M.W.I.) afford corresponding pyrazoles (8a-b, 9a-b). The hydrazones (4a-b, 5a-b) on reacting with chloroacetylchloride/thioglycollic acid furnish corresponding 2-azetidinones (10a-b, 11a-b) and 4-thiazolidinones (12a-b, 13a-b) respectively. The hydrazones (6a-b, 7a-b) cyclise in the presence of polyphosphoric acid under M.W.I, to give corresponding benzopyran-2-ones (14a-b, 15a-b). The hydrazides 1a-b on condensation with aromatic acids in the presence of thionyl chloride yield corresponding 1,3,4-oxadiazoles (16a-b, 17a-b).
Microwave-Assisted Synthesis of 1,3,4-Thiadiazolyl-Substituted 1,2,4,5-Tetrazines, Pyridazinones, 1,2,4-Triazoles, 4-Thiazolidinones, Oxazoles and Thiazoles
Kidwai, Mazaahir,Kumar, Rajesh
, p. 263 - 268 (2007/10/03)
(5-Methyl-1,3,4-thiadiazol-2-ylsulfanyl)acetohydrazide, 1, has been prepared and allowed to react with substituted benzaldehydes or acetophenones to yield the corresponding hydrazones 2a-j.These hydrazones, on condensation with 2-hydrazino-4-methylquinoline under microwave irradiation and by conventional methods, yielded the tetrazines 3a-j.In comparison with the conventional method the reaction rate is enhanced about 250 times by using microwaves and yields are improved. 1 on reaction with chloroacetic acid, dichloroacetic acid, and chloroacetyl chloride yielded the pyridazinones 4-6, while on reaction with phenyl isothiocyanate and phenyl isocyanate yielded the thiosemicarbazide 7a and semicarbazide 7b which have been elaborated further to the thiazole 8a, the oxazole 8b, the thiazolidinone 9 and the triazole 10.
