190790-85-3Relevant articles and documents
Method for preparing 7-phenylacetyl amino-3-allyl-4-cefazolin acid p-methoxybenzyl acetate
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Paragraph 0028, (2017/01/02)
The invention discloses a method for preparing 7-phenylacetyl amino-3-allyl-4-cefazolin acid p-methoxybenzyl acetate, and relates to the technical field of preparation of cephalosporin medical intermediates. The method comprises the following steps that 1, a compound I, sodium bromide, potassium iodide and triphenylphosphine react in a mixed solution of dichloromethane and water, and a compound III is obtained; 2, after the reaction in the step 1 is finished, a water layer in the step 1 is separated out, alkali liquor is dropwise added into an organic layer in the step 1 for reacting, and a compound IV is obtained; 3, after the reaction in the step 2 is finished, a water layer in the step 2 is separated and recycled and circularly used for the reaction in the step 1, and the addition of sodium bromide and potassium iodide is reduced; a solvent and acetaldehyde are added into an organic layer in the step 2 for a Wittig reaction, and a compound V is prepared. According to the method, after the alkali liquor is added to generate the compound IV, the water phase can be used for circulated to be applied to the next reaction, use of sodium bromide and potassium iodide is saved, and the production cost is reduced.
Synthesis of 3-alkenyl-Δ3-cephems via sequential reductive 1,2- elimination/ addition/cyclization in an alkenyltin/copper(I) chloride/bpy system
Tanaka, Hideo,Tokumaru, Yoshihisa,Torii, Sigeru
, p. 774 - 776 (2007/10/03)
A sequential reductive 1,2-elimination-addition-cyclization of 3,4- disubstituted butenoates derived from penicillin is performed successfully by treatment with alkenyltin, copper(I) chloride and 2,2'-bipyridine (bpy) in N- methyl-2-pyrrolidinone (NMP) to afford 3-alkenyl-Δ3-cephems.
