1908-01-6

Basic information

• Product Name: 5-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ETHYL 5-METHYL-1H-INDAZOLE-3-CARBOXYLATE;5-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER;1H-Indazole-3-carboxylic acid, 5-methyl-, ethyl ester;5-Methyly-1H-indazole-3-carboxylic acid ethyl ester
• CAS NO: 1908-01-6
• Molecular Formula: C11H12N2O2
• Molecular Weight: 204.23
• Mol File: 1908-01-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 368.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.232±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.16±0.40(Predicted)
• CAS DataBase Reference: 5-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(1908-01-6)
• EPA Substance Registry System: 5-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(1908-01-6)

Safety Data

• Hazardous Substances Data: 1908-01-6(Hazardous Substances Data)

Usage

General Description

5-Methyl-1H-indazole-3-carboxylic acid ethyl ester is a chemical compound with the molecular formula C11H11NO2. It is an ester of 5-methyl-1H-indazole-3-carboxylic acid and ethyl alcohol. 5-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceutical drugs. It is also employed as a building block in the production of agrochemicals and other organic compounds. 5-Methyl-1H-indazole-3-carboxylic acid ethyl ester is a versatile chemical with diverse applications in the manufacturing of different products.

Upstream product

• 608-05-9 5-methyl-indole-2,3-dione 
• 64-17-5 ethanol 
• 1201-24-7 5-methyl-1H-indazole-3-carboxylic acid 
• 623-73-4 diazoacetic acid ethyl ester 
• 262373-15-9 4-methyl-2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 1448314-58-6 5-methyl-1-(3-methylbenzoyl)-1H-indazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Preparation methods of 1H-indazol-3-carboxylic acid derivative, granisetron and lonidamine

The invention relates to preparation methods of a 1H-indazol-3-carboxylic acid derivative, granisetron and lonidamine. The 1H-indazol-3-carboxylic acid derivative is a compound with a structure shown in a formula (1) and a formula (2), and is mainly structurally characterized by having a 1H-indazol-3-carboxylic acid amide skeleton and a 1H-indazol-3-carboxylic ester skeleton. The 1H-indazol-3-carboxylic acid derivative can be synthesized by taking simple o-aminophenylacetic acid amide or o-aminophenylacetic acid ester as an initial raw material. The 1H-indazol-3-carboxylic acid derivative is a key intermediate for synthesizing a plurality of medicines, such as granisetron, lonidamine and the like. The synthesis method of the 1H-indazol-3-carboxylic acid derivative and the drug molecules glassetron and lonidamine is simple, the reaction condition is mild, the reaction speed is high, the yield is high, and purification is easy.

Facile and efficient synthesis of indazole derivatives by 1,3-cycloaddition of arynes with diazo compounds and azomethine imides

N-Unsubstituted indazoles 3 and 1-arylindazoles 4 are readily available in good to high yields through [3+2] cycloaddition of 2-(trimethylsilyI)aryl triflates 1 and diazo compounds in the presence of KF or CsF under mild reaction conditions. Furthermore, we found that azomethine imides also underwent cycloaddition reaction with 2-(trimethylsilyl)phenyl triflates (la) in the presence of KF to afford indazolone derivatives 6 in moderate yields.

Synthesis of some derivatives of 5 methylindazole 3 carboxylic acid

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