190834-04-9Relevant academic research and scientific papers
Dual inhibition of human leukocyte elastase and lipid peroxidation: In vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives
Portevin, Bernard,Lonchampt, Michel,Canet, Emmanuel,De Nanteuil, Guillaume
, p. 1906 - 1918 (2007/10/03)
A series of potent and selective human leukocyte elastase (HLE) inhibitors of the Val-Pro-Val type has been developed. Initially, the central proline residue was replaced by nonnatural amino acids Phi ((2S,3aS,7aS)- perhydroindole-2-carboxylic acid) and A
