190845-14-8Relevant academic research and scientific papers
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl] acridine- 4-carboxamide
Spicer, Julie A.,Gamage, Swarna A.,Atwell, Graham J.,Finlay, Graeme J.,Baguley, Bruce C.,Denny, William A.
, p. 1919 - 1929 (1997)
The mixed topoisomerase I/II inhibitor N-[2- (dimethylamino)ethyl]acridine-4-carboxamide (DACA) is currently in clinical trial as an anticancer drug. A series of acridine-substituted analogues were prepared, using a new synthetic route to substituted acri
