190902-20-6

Upstream product

• 190902-19-3 (1RS,2S,3R)-2,3-bis(methoxymethyl)oxy-4-(t-butyldimethylsilyl)oxy-1-cyano-N-(4-methoxybenzyl)butanamide 
• 166542-98-9 (2R,3R)-2,3-bis(methoxymethoxy)-4-<(t-butyldimethylsilyl)oxy>-1-butanol 
• 166542-99-0 (2S,3R)-2,3-bis(methoxymethoxy)-4-<(t-butyldimethylsilyl)oxy>butanal 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 190902-21-7 (3S,4R,5RS)-N-(4-methoxybenzyl)-3,4-bis(methoxymethyl)oxy-5-cyano-2-pyrrolidinone 
• 245484-38-2 (3S,4R,5R)-N-(4-methoxybenzyl)-3,4-bis(methoxymethyl)oxy-5-iodomethyl-2-pyrrolidinone 
• 245484-40-6 (3S,4R,5R)-N-(4-methoxybenzyl)-3,4-bis(methoxymethyl)oxy-5-methyl-2-pyrrolidinone 
• 190902-29-5 (3S,4R,5S)-N-(4-methoxybenzyl)-3,4-bis(methoxymethyl)oxy-5-(t-butyldiphenylsiloxymethyl)-2-pyrrolidinone 
• 190902-24-0 (3S,4R,5R)-N-(4-methoxybenzyl)-3,4-bis(methoxymethyl)oxy-5-(t-butyldiphenylsiloxymethyl)-2-pyrrolidinone 
• 190902-31-9 (3S,4R,5S)-N-(t-butoxycarbonyl)-3,4-bis(methoxymethyl)oxy-5-(t-butyldiphenylsiloxymethyl)-2-pyrrolidinone 
• 190902-26-2 (3S,4R,5R)-N-(t-butoxycarbonyl)-3,4-bis(methoxymethyl)oxy-5-(t-butyldiphenylsiloxymethyl)-2-pyrrolidinone 
• 190902-32-0 (3S,4R,5S)-N-(t-butoxycarbonyl)-2-hydroxy-3,4-bis(methoxymethyl)oxy-5-(t-butyldiphenylsiloxymethyl)pyrrolidine 
• 190902-27-3 (3S,4R,5R)-N-(t-butoxycarbonyl)-2-hydroxy-3,4-bis(methoxymethyl)oxy-5-(t-butyldiphenylsiloxymethyl)pyrrolidine 
• 190902-25-1 (3S,4R,5R)-3,4-bis(methoxymethyl)oxy-5-(t-butyldiphenylsiloxymethyl)-2-pyrrolidinone 
• 190902-30-8 (3S,4R,5S)-3,4-bis(methoxymethyl)oxy-5-(t-butyldiphenylsiloxymethyl)-2-pyrrolidinone 
• 190902-23-9 (3S,4R,5R)-N-(4-methoxybenzyl)-3,4-bis(methoxymethyl)oxy-5-hydroxymethyl-2-pyrrolidinone 
• 190902-34-2 (3S,4R,5S)-N-(4-methoxybenzyl)-3,4-bis(methoxymethyl)oxy-5-hydroxymethyl-2-pyrrolidinone 
• 190902-22-8 (3S,4R,5RS)-N-(4-methoxybenzyl)-3,4-bis(methoxymethyl)oxy-5-methoxycarbonyl-2-pyrrolidinone 

Relevant academic research and scientific papers

Novel synthesis of nectrisine and 4-epi-nectrisine

Nectrisine 1, a potent glycosidase inhibitor, and 4-epi-Nectrisine 2 were synthesized from D-(-)-diethyl tartrate through the corresponding lactams. N-acyl protection was crucial to effect the reduction of the corresponding lactams to amino alcohols.

Synthesis of nectrisine and related compounds, and their biological evaluation

An efficient and novel process is described for the synthesis of nectrisine 5 and its related derivatives 6,7 as potent glucosidase inhibitors via the corresponding lactams starting from D-(-)-diethyl tartrate. Also the results of biological evaluation of the synthesized compounds are described.