Novel synthesis of nectrisine and 4-epi-nectrisine

DOI: 10.1016/S0040-4039(97)00636-9

Source and publish data:

Tetrahedron Letters p. 3423 - 3426 (1997)

Update date:2022-08-04

Topics:

Authors:

Kim, Yong Jip

Kitahara, Takeshi

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Article abstract of DOI:10.1016/S0040-4039(97)00636-9

Nectrisine 1, a potent glycosidase inhibitor, and 4-epi-Nectrisine 2 were synthesized from D-(-)-diethyl tartrate through the corresponding lactams. N-acyl protection was crucial to effect the reduction of the corresponding lactams to amino alcohols.

Full text of DOI:10.1016/S0040-4039(97)00636-9

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