190904-23-5Relevant articles and documents
Novel acylguanidine containing thrombin inhibitors with reduced basicity at the P1 moiety
Adang, Anton E.P.,Lucas, Hans,De Man, Adrianus P.A.,Engh, Richard A.,Grootenhuis, Peter D.J.
, p. 3603 - 3608 (2007/10/03)
Replacement of the noragmatine group in thrombin inhibitors with a β- alanyl-guanidine group resulted in a nearly equipotent and more selective compound 8 despite the fact that the pK(a) of this P1 moiety is five orders of magnitude lower. Furt