190905-50-1Relevant academic research and scientific papers
A general copper-mediated nucleophilic 18F fluorination of arenes
Tredwell, Matthew,Preshlock, Sean M.,Taylor, Nicholas J.,Gruber, Stefan,Huiban, Mickael,Passchier, Jan,Mercier, Joel,Genicot, Christophe,Gouverneur, Veronique
, p. 7751 - 7755 (2014/08/05)
Molecules labeled with fluorine-18 are used as radiotracers for positron emission tomography. An important challenge is the labeling of arenes not amenable to aromatic nucleophilic substitution (SNAr) with [ 18F]F-. In the
Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith
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Page/Page column 38, (2008/12/07)
Provided herein are Heterocyclic Compounds having the following structure: wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.
Macrocyclic inhibitors of β-secretase: Functional activity in an animal model
Stachel, Shawn J.,Coburn, Craig A.,Sankaranarayanan, Sethu,Price, Eric A.,Pietrak, Beth L.,Huang, Qian,Lineberger, Janet,Espeseth, Amy S.,Jin, Lixia,Ellis, Joan,Holloway, M. Katharine,Munshi, Sanjeev,Allison, Timothy,Hazuda, Daria,Simon, Adam J.,Graham, Samuel L.,Vacca, Joseph P.
, p. 6147 - 6150 (2007/10/03)
A macrocyclic inhibitor of β-secretase was designed by covalently cross-linking the P1 and P3 side chains of an isophthalamide-based inhibitor. Macrocyclization resulted in significantly improved potency and physical properties when compared to the initia
Efficient Access to Alanine Derivatives by 1,4-Additions of Potassium Trifluoro(organo)borates
Navarre, Laure,Darses, Sylvain,Genet, Jean-Pierre
, p. 69 - 73 (2007/10/03)
Potassium trifluoro(organo)borates, highly stable and easily prepared organoboran derivatives, were able to react with a great variety of dehydroamino esters. This reaction, catalyzed by rhodium complexes, allowed the formation of alanine derivatives bearing a great variety of amino protecting groups in good to high yields.
