190953-67-4Relevant academic research and scientific papers
N,N′-disubstituted cinnamamide derivatives potentiate ciprofloxacin activity against overexpressing NorA efflux pump Staphylococcus aureus 1199B strains
Radix, Sylvie,Jordheim, Anne Doléans,Rocheblave, Luc,N'Digo, Serge,Prignon, Anne-Laure,Commun, Carine,Michalet, Serge,Dijoux-Franca, Marie-Geneviève,Mularoni, Angélique,Walchshofer, Nadia
, p. 900 - 907 (2018/04/03)
A multi-step procedure has been described which afforded satisfactory yields of N,N′-disubstituted cinnamamides derived from N-Boc-protected amino acids (Boc-Gly, Boc-Val, Boc-Phe). The key step of this synthesis was a regioselective RedAl reduction of an
Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis
Thanigaimalai,Lee, Ki-Cheul,Bang, Seong-Cheol,Lee, Jee-Hyun,Yun, Cheong-Yong,Roh, Eunmiri,Hwang, Bang-Yeon,Kim, Youngsoo,Jung, Sang-Hun
experimental part, p. 1135 - 1142 (2010/04/24)
The series of imidazoldine-2-thiones 2 and tetrahydropyrimidine-2-thiones 3 were discovered as inhibitor of α-MSH-induced melanin production in melanoma B16 cells. The primary bioassay showed that 1-(4-ethylbenzyl)-tetrahydropyrimidine-2(1H)-thione 3e (>1
3-(piperazinylpropyl)indoles: Selective, orally bioavailable h5-HT(1D) receptor agonists as potential antimigraine agents
Chambers, Mark S.,Street, Leslie J.,Goodacre, Simon,Hobbs, Sarah C.,Hunt, Peter,Jelley, Richard A.,Matassa, Victor G.,Reeve, Austin J.,Sternfeld, Francine,Beer, Margaret S.,Stanton, Josephine A.,Rathbone, Denise,Watt, Alan P.,MacLeod, Angus M.
, p. 691 - 705 (2007/10/03)
Clinically effective antimigraine drugs such as Sumatriptan have similar affinity at h5-HT(1D) and h5-HT(1B) receptors. In the search for a h5- HT(1D)-selective agonist as an antimigraine agent, a novel series of 3- (propylpiperazinyl)indoles have been sy
