190959-15-0Relevant academic research and scientific papers
Synthesis and spectroscopic pecullarities of 11β-aryl-estra-4,8(14),9-trienes and 11β-aryl-estra-5(10),6,8-trienes
Neef, Guenter,Cleve, Arwed,Depke, Gisbert,Eckle, Emil
, p. 3897 - 3900 (1997)
A synthetic strategy is disclosed for the introduction of an additional conjugate 8(14) double bond into 11β-arylsubstituted antiprogestins of the RU 486 type. Ring B aromatic analogues are obtained as by-products. Both structural variations markedly affect the rotational behaviour of the 11β-phenyl residue.
