Tetrahedron Letters p. 3897 - 3900 (1997)
Update date:2022-08-02
Topics:
Neef, Guenter
Cleve, Arwed
Depke, Gisbert
Eckle, Emil
A synthetic strategy is disclosed for the introduction of an additional conjugate 8(14) double bond into 11β-arylsubstituted antiprogestins of the RU 486 type. Ring B aromatic analogues are obtained as by-products. Both structural variations markedly affect the rotational behaviour of the 11β-phenyl residue.
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