Synthesis and spectroscopic pecullarities of 11β-aryl-estra-4,8(14),9-trienes and 11β-aryl-estra-5(10),6,8-trienes

DOI: 10.1016/S0040-4039(97)00763-6

Source and publish data:

Tetrahedron Letters p. 3897 - 3900 (1997)

Update date:2022-08-02

Topics:

Authors:

Neef, Guenter

Cleve, Arwed

Depke, Gisbert

Eckle, Emil

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Article abstract of DOI:10.1016/S0040-4039(97)00763-6

A synthetic strategy is disclosed for the introduction of an additional conjugate 8(14) double bond into 11β-arylsubstituted antiprogestins of the RU 486 type. Ring B aromatic analogues are obtained as by-products. Both structural variations markedly affect the rotational behaviour of the 11β-phenyl residue.

Full text of DOI:10.1016/S0040-4039(97)00763-6

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