19096-10-7Relevant academic research and scientific papers
Identification of (S)-11-cycloheptyl-4-methylundecanoic acid in acylphosphatidylglycerol from Alicyclobacillus acidoterrestris
Rezanka, Tomas,Siristova, Lucie,Melzoch, Karel,Sigler, Karel
experimental part, p. 104 - 113 (2010/03/03)
A method is described for the identification of molecular species of acylphosphatidylglycerols containing a branched cyclo fatty acid ((S)-11-cycloheptyl-4-methylundecanoic acid; brc19:0) from Alicyclobacillus acidoterrestris and its identification as picolinyl ester by means of GC-MS. The combination of TLC, negative RP-HPLC-ESI-MS/MS, enzymatic hydrolysis, and GC-MS was used to identify unusual molecular species of acylphosphatidylglycerols with cyclic and branched FA. The acid, brc19:0, was also synthesized to unambiguously confirm its structure. According to feeding experiments with 13C-labeled propionate, the C3 internal unit (branched methyl) of brc19:0 is assembled from propionate and not from methionine.
Pentanedioic acid derivatives
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, (2008/06/13)
Compounds of formula I are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit β-hydroxy-β-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthesis of serum cholesterol.
