190974-74-4Relevant academic research and scientific papers
Rhenium diazenide ternary complexes with dithiocarbamate ligands: Towards new rhenium radiopharmaceuticals
Cowley, Andrew R.,Dilworth, Jonathan R.,Donnelly, Paul S.,Ross, Susan J.
, p. 73 - 82 (2007/10/03)
The reaction of the mono-diazenide core, [ReCl2(NNC 6H4-4-OCH3)(NCCH3)(PPh 3)2], with four equivalents of the sodium or potassium salts of dithiocarbamate (dtc) ligands gives neutral complexes of the formula [Re(NNC6H4-4-OCH3)(dtc)2(PPh 3)]. It is possible to use a wide range of dithiocarbamate ligands (S2CNRR′) with a variety of R groups (R = R′ = methyl, phenyl or ethyl; R = methyl, R′ = phenyl and R = R′ = morpholino). Substitution reactions with dtc ligands on the mono-diazenide derived from 2-hydrazinopyridine, [ReCl2(NNC5H4N)(PPh 3)2, give the analogous complexes, [Re(NNC 6H5N)(dtc)2(PPh3)]. The new complexes have been characterised by a combination of NMR spectroscopy, mass spectrometry and X-ray crystallography. Cyclic voltammetry measurements in dimethyl formamide show that the rhenium diazenido-dtc complexes undergo a quasi-reversible oxidation tentatively assigned to a ReIII/Re IV oxidation. Since the parent complex, [ReCl2(NNC 6H4-4-R)(NCCH3)(PPh3)2] can be prepared directly from perrhenate and readily derivatised with dtc ligands these complexes have potential relevance to the development of new therapeutic rhenium radiopharmaceuticals. This journal is The Royal Society of Chemistry.
Synthesis and Characterization of Rhenium(III) and Technetium(III) Organohydrazide Chelate Complexes. Reactions of 2-Hydrazinopyridine with Complexes of Rhenium and Technetium
Hirsch-Kuchma, Melissa,Nicholson, Terrence,Davison, Alan,Davis, William M.,Jones, Alun G.
, p. 3237 - 3241 (2008/10/09)
The organohydrazide chelate complexes MIII(NNpy)(PPh3)2Cl2. (1, 3) (M = Re, Tc) have been synthesized using the organohydrazine 2-hydrazinopyridine. The chelated organohydrazide is a diazenido (1-) ligand that forms a five-membered ring with the metal center. An X-ray structural analysis of 1 indicates that there is a delocalized π-system formed by the chelate ring. These octahedral, d4 metal complexes have diamagnetic 1H NMR spectra. Complex 1. C41.50H34Cl2N3O 0.5P2Re, crystallizes in the triclnic space group P1 with a = 10.5549(7) A, b = 12.2699(8) A, c = 16.8206(12) A, α = 105.9050(10)°, β= 95.8930(10)°, γ = 111.0100(10)°, V= 1906.1(2) A3, Z = 2, and R = 0.0650 based on 5268 unique reflections. The FAB MS-+ in (p-nitrobenzyl alcohol) of 3 reveals a parent ion peak at m/z 799.2. The complex [Re(HNNpy)(NNpy)(PMe2Ph)2Cl]+[Cl] (2) contains a chelated, neutral organodiazene ligand and a linear, diazenido(1-) ligand. The X-ray structural analysis of 2, C26H30Cl2N6P2Re, indicates a delocalized π-system formed by the chelate ring. The 1H NMR spectrum of 2 is not paramagnetically shifted. Complex 2 crystallizes in the orthorhombic space group Pna21 with a -17.383(4) A, b = 13.967(3) A, c = 12.002(2) A, V = 2913.9(10) A3, Z = 4, and R = 0.0384 based on 3083 unique reflections.
