19099-60-6Relevant academic research and scientific papers
A novel approach to 2-chloro-2-fluorostyrenes
Nenajdenko, Valentine G.,Shastin, Alexey V.,Korotchenko, Vasily N.,Varseev, Georgy N.,Balenkova, Elisabeth S.
, p. 302 - 308 (2003)
A new general catalytic olefination reaction (COR) of aromatic and heteroaromatic aldehydes and ketones was applied to synthesise 2-chloro-2-fluorostyrenes. The two-stage procedure includes the transformation of carbonyl compounds into hydrazones followed by treatment with CFCl3 mediated by copper catalysis. Trichlorofluoromethane was used as a chlorofluoromethylene transfer reagent. The reaction proceeds stereoselectively and the target alkenes were obtained in high yield. A proposed mechanism for the reaction is discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
Synthesis of fluorinated olefins via the palladium catalyzed cross- coupling reaction of 1-fluorovinyl halides with organoboranes
Chen, Chen,Wilcoxen, Keith,Strack, Nathalie,McCarthy, James R.
, p. 827 - 830 (2007/10/03)
The palladium catalyzed cross-coupling reaction of 1-fluorovinyl halides 1-4 with organoboranes proceeds under Suzuki conditions with retention on configuration to give 1-substituted 1-fluoroolefins 6-8 in good to excellent yields.
