191013-97-5Relevant academic research and scientific papers
Asymmetric deprotonation of N -boc piperidine: React IR monitoring and mechanistic aspects
Stead, Darren,Carbone, Giorgio,O'Brien, Peter,Campos, Kevin R.,Coldham, Iain,Sanderson, Adam
supporting information; experimental part, p. 7260 - 7261 (2010/07/13)
The high yielding asymmetric deprotonation trapping of N-Boc piperidine is successfully realized using s-BuLi and a (+)-sparteine surrogate. Monitoring of the lithiation by in situ React IR allowed the direct observation of a prelithiation complex.
Asymmetrie substitutions of 2-lithiated N-boc-piperidine and N-boc-azepine by dynamic resolution
Coldham, Iain,Raimbault, Sophie,Whittaker, David T. E.,Chovatia, Praful T.,Leonori, Daniele,Patel, Jignesh J.,Sheikh, Nadeem S.
experimental part, p. 4082 - 4090 (2010/07/10)
Proton abstraction of N-tertbutoxycarbonyl-piperidine (N-Boc-piperidine) with sBuLi and TMEDA provides a racemic organolithium that can be resolved using a chiral ligand. The enantiomeric organolithiums can interconvert so that a dynamic resolution occurs. Two mechanisms for promoting enantioselectivity in the products are possible. Slow addition of an electrophile such as trimethylsilyl chloride allows dynamic resolution under kinetic control (DKR). This process occurs with high enantioselectivity and is successful by catalysis with substoichiometric chiral ligand (catalytic dynamic kinetic resolution). Alternatively, the two enantiomers of this organolithium can be resolved under thermodynamic control with good enantioselectivity (dynamic thermodynamic resolution, DTR). The best ligands found are based on chiral diamino-alkoxides. Using DTR, a variety of electrophiles can be used to provide an asymmetric synthesis of enantiomerically enriched 2-substituted piperidines, including (after Boc deprotection) the alkaloid (+)-ss-conhydrine. The chemistry was extended, albeit with lower yields, to the corresponding 2-substituted sevenmembered azepine ring derivatives.
Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine
Coldham, Iain,Patel, Jignesh J.,Raimbault, Sophie,Whittaker, David T. E.
, p. 4534 - 4536 (2008/09/16)
Asymmetric substitution of 2-lithiopiperidines can be achieved by dynamic resolution; the organolithium is formed as a racemic mixture by proton abstraction (or tin-lithium exchange) and is resolved in the presence of a chiral ligand. The Royal Society of
