191084-12-5Relevant academic research and scientific papers
Synthesis, cytotoxicity, and DNA-topoisomerase inhibitory activity of new asymmetric ureas and thioureas
Esteves-Souza, Andressa,Pissinate, Kenia,Graca Nascimento, Maria Da,Grynberg, Noema Faiga,Echevarria, Aurea
, p. 492 - 499 (2007/10/03)
A new series of N-3,3-diphenylpropyl-N-(p-X-benzyl)-N′-phenylureas (5a-g) and thioureas (6a-g) were synthesized by the reaction of secondary amines and phenyl isocyanate or isothiocyanate. The cytotoxic effects of the urea and thiourea derivatives were ev
Rapid purification of small molecule libraries by ion exchange chromatography
Siegel, Miles G.,Hahn, Patric J.,Dressman, Bruce A.,Fritz, James E.,Grunwell, Jocelyn R.,Kaldor, Stephen W.
, p. 3357 - 3360 (2007/10/03)
Amines and acylated amines are synthesized in traditional solution phase reactions, then rapidly purified by ion exchange chromatography to yield pure products. In some instances, impurities devoid of ionizable functionality can be covalently modified pri
