191087-88-4Relevant academic research and scientific papers
Diastereoselective Michael Addition of Nitrogen and Sulfur-Nucleophiles to α,β-Unsaturated δ-Thiolactams
Sosnicki, Jacek G.,Jagodziriski, Tadeusz S.,Liebscher, Juergen
, p. 643 - 648 (1997)
5,6-Dihydropyridine-2-thiones 2 are synthesized from 5,6-dihydropyridin-2-ones 1 and Lawesson reagent. Stereoselective Michael-like addition of amines, methylhydrazine or functionalized thiols affords trans piperidine-2-thiones 5 with the corresponding heterosubstituent in position 4 as major products. The configuration of the adducts 5 was determined by nmr-techniques.
