107520-59-2

Upstream product

• 85636-50-6 1-(trimethylsiloxy)-1-methoxy-1,3-butadiene 
• 780-25-6 N-benzylidene benzylamine 
• 85390-58-5 but-3-enoic acid benzylamide 
• 100-52-7 benzaldehyde 
• 431982-25-1 N-benzyl-N-(1-phenylbut-3-enyl)acrylamide 
• 933803-10-2 1-benzyl-6-phenylpiperidin-2-one 
• 1121-89-7 piperidine-2,6-dione 
• 41267-62-3 1-benzyl-6-phenyl-3,4-dihydropyridin-2(1H)-one 
• 42856-43-9 1-benzylpiperidine-2,6-dione 
• 100-39-0 benzyl bromide 
• 88381-98-0 N-(1-phenyl-3-butenyl)benzylamine 
• 100-46-9 benzylamine 
• 67-66-3 chloroform 

Downstream Products

• 191087-88-4 1-Benzyl-6-phenyl-3,6-dihydro-1H-pyridine-2-thione 
• 191087-75-9 1-Benzyl-6-phenyl-5,6-dihydro-1H-pyridine-2-thione 

Relevant academic research and scientific papers

Dimethylzinc-Mediated Chlorolactamization of Homoallylic Amines with Chloroform

A novel chlorolactamization reaction of homoallylic amines has been developed. The treatment of homoallylic amines with dimethylzinc in chloroform led to the formation of the corresponding β-chlorolactams via the Prins-type cyclization of a carbamoyl chlo

Concise and short synthesis of functionalized 5,6-dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates

A concise and short synthetic entry to 5,6-dihydropyridin-2-one derivatives has been developed by means of palladium(0)-catalyzed cross-coupling of cyclic ketene aminal phosphates.

Synthesis of conjugated δ-lactams using ring-closing metathesis

Addition of allyl magnesium or metallyl magnesium bromide to the N-benzyl imines of benzaldehyde and cyclohexanone, followed by acylation with acryloyl or metacryloyl chloride provided the corresponding α,β-unsaturated amides. Ring-closing metathesis of the latter with ruthenium catalyst PhCH=RuCl2(PPh3)2 in the presence of Ti(OiPr)4 provided excellent yields of the corresponding conjugated δ-lactams with both disubstituted and trisubstituted C=C bonds. Some specific trisubstitution patterns, however, as well as tetrasubstituted C=C bonds, were not obtained. In these cases, even the use of a second generation, imidazolylidene-substituted ruthenium catalyst at high temperature did not lead to success.

Stereoselective syntheses of substituted 5,6-dihydro-2(1H)-pyridinones in polyphosphate media

δ-Lactams have been synthesized with excellent stereocontrol of substituents by condensing 3-alkenamides with aryl aldehydes in polyphosphoric ester. The scope of the condensation of 3-alkenamides with aryl aldehydes in several phosphate media is examined, and a rationale is proposed regarding γ-lactam versus δ-lactam formation.

Stereocontrolled Syntheses of Substituted Unsaturated δ-Lactams from 3-Alkenamides

δ-Lactams have been synthesized with excellent stereocontrol of substituents by condensing 3-alkenamides with aryl aldehydes in polyphosphoric ester.

REACTIONS OF KETENE SILYL ACETALS WITH IMINE-COMPLEXES OF TITANIUM TETRACHLORIDE. NEW AND CONVENIENT ROUTES TO 5,6-DIHYDRO-2-PYRIDONES AND 5-AMINO-2-ALKENOATES

The reactions of vinylketene silyl acetals (VKSAs) with imine complexes of TiCl4 give the corresponding 5,6-dihydro-2-pyridones and/or 5-amino-2-alkenoates in good to excellent yields.It is suggested that an addition-cyclization mechanism is operative for the formation of 5,6-dihydro-2-pyridones in this formal cyclocondensation reaction.