191092-07-6

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-3-(Tosyloxymethyl)-N-Boc-piperidine is used as a key building block for the development of new pharmaceuticals. Its unique structure allows for the creation of a diverse range of medicinal compounds, contributing to advancements in drug discovery and design.
Used in Organic Chemistry Research:
In the field of organic chemistry, (R)-3-(Tosyloxymethyl)-N-Boc-piperidine is employed as a valuable tool for studying reaction mechanisms and exploring new synthetic pathways. Its reactivity and structural features facilitate the investigation of various organic reactions and the development of innovative methodologies.
Used in Chemical Synthesis Education:
(R)-3-(Tosyloxymethyl)-N-Boc-piperidine can also be utilized as an educational tool in teaching organic chemistry, particularly in illustrating the concepts of protecting groups, leaving groups, and the synthesis of complex organic molecules. Its structure and reactivity make it an ideal candidate for demonstrating various organic reactions and techniques in a controlled and educational setting.

Upstream product

• 116574-71-1 tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 4124-41-8 p-toluenesulfonylanhydride 
• 25137-01-3 (R)-ethyl nipecotate 
• 37675-20-0 (R)-3-hydroxymethyl piperidine 

Downstream Products

• 1187465-61-7 (R,Z)-tert-butyl 3-((5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)methyl)piperidine-1-carboxylate 
• 1393331-68-4 C₂₁H₂₂BrFN₄O₂ 
• 1393331-70-8 (R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine 
• 1393331-67-3 [18F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine 
• 1093988-80-7 1,1-dimethylethyl (3R)-3-[({4-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-3-methylphenyl}oxy)methyl]-1-piperidinecarboxylate 

Relevant academic research and scientific papers

Synthesis and in vitro evaluation of [18F](R)-FEPAQ: A potential PET ligand for VEGFR2

Synthesis and in vitro evaluation of [18F](R)-N-(4-bromo-2- fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin- 4-amine ((R)-[18F]FEPAQ or [18F]1), a potential imaging agent for the VEGFR2, usin

N-ACYL CYCLIC AMINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

The present invention provides compounds which show high effectiveness against positive symptoms, negative symptoms and cognitive dysfunction in schizophrenia and reduce conventional side-effect risks as well as have remarkable effects for central neurolo

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

Disclosed herein are compounds of formula (I) wherein R1, R2, R3, R25a, R26a, X, and n are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions are also described

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

Novel Compounds

Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein X, R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES

The present invention provides a process for preparing benzimidazole thiophene compounds of formula I. Intermediates used in the process are also claimed.

Synthesis of substituted 1H-imidazol-1-ylmethylpiperidines. Facile separation of 1,4- and 1,5-disubstituted imidazoles

The synthesis of several 1H-imidazol-1-ylmethylpiperidines is described. A method for the regioselective isolation of 1,4-disubstituted imidazoles utilizing the selective quaternization of the 1,5-disubstituted regioisomer was developed.