191110-48-2

Upstream product

• 100-39-0 benzyl bromide 
• 54307-67-4 1-bromo-2-benzyloxy-3-chloropropane 
• 54166-15-3 diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate 

Downstream Products

• 222727-33-5 1-t-butyl carbamate-3-benzyloxy-1-cyclobutane-1-carboxylic acid methyl ester 
• 222727-31-3 1-t-butyl carbamate-3-benzyloxy-1-cyclobutane-1-carboxylic acid 
• 222727-29-9 1-amino-3-benzyloxycyclobutane-1-carboxylic acid 
• 191110-49-3 2-(benzyloxy)-5,7-diazaspiro[3.4]octane-6,8-dione 

Relevant academic research and scientific papers

SOLID-PHASE PREPARATION OF 18F-LABELLED AMINO ACIDS

A process for the production of an 18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2-O -TRACER (I) with 18F- to produce the labelled tracer of formula (II).

Synthesis of [F-18]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC): A pet tracer for tumor delineation

Fluorine-18 labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC), a new tumor-avid amino acid, was synthesized for positron emission tomography. [18F]FACBC was prepared with high specific activity by nucleophilic displacement with an o