1912-47-6

Usage

Uses

Used in Agricultural Industry:
5-METHYLINDOLE-3-ACETIC ACID is used as a plant growth regulator for enhancing plant growth and development. It stimulates cell division and elongation, leading to improved crop yields and overall plant health.
Used in Plant Biotechnology:
In the field of plant biotechnology, 5-METHYLINDOLE-3-ACETIC ACID is utilized as a tool to study the mechanisms underlying plant growth and development. Understanding its role in cell division and elongation can provide valuable insights into the genetic and molecular processes that govern these essential aspects of plant life.

Upstream product

• 692-29-5 Succinic semialdehyde 
• 539-44-6 N-4-methylphenylhydrazine 
• 614-96-0 5-methyl-1H-indole 
• 115956-14-4 2-(5-methyl-1H-indol-3-yl)-2-oxoacetyl chloride 
• 156695-43-1 (5-Methyl-1H-indol-3-yl)-oxo-acetic acid 
• 65881-14-3 2-(5-methyl-1H-indol-3-yl)acetonitrile 
• 1337870-84-4 (5-methyl-indol-3-yl)-acetic acid methyl ester 

Downstream Products

• 1337870-84-4 (5-methyl-indol-3-yl)-acetic acid methyl ester 
• 442883-72-9 5-methyl-3-methylene-2-oxindole 
• 924635-02-9 2-(1-(benzyloxycarbonyl)-5-methyl-1H-indol-3-yl)acetic acid 
• 924635-03-0 benzyl 3-(3-chloro-2-oxopropyl)-5-methyl-1H-indole-1-carboxylate 
• 924633-74-9 benzyl 3-(3-acetoxy-2-oxopropyl)-5-methyl-1H-indole-1-carboxylate 
• 1383933-36-5 N-benzyl-2-(1,5-dimethyl-1H-indol-3-yl)acetamide 
• 1383933-35-4 C₁₈H₁₈N₂O 
• 39595-23-8 2-(5-methyl-1H-indol-3-yl)ethan-1-ol 
• 91957-21-0 5-methyl-1H-indole-3-acetic acid ethyl e 

Relevant academic research and scientific papers

TETRAHYDROISOQUINOLINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF

Disclosed are a novel tetrahydroisoquinoline compound, a method for preparing intermediates thereof, a pharmaceutical composition thereof and the use thereof. The tetrahydroisoquinoline compound of the present invention has a good inhibitory effect on phosphodiesterase (PDE4), and can be used in the prevention, treatment or auxiliary treatment of multiple diseases associated with the activity or expression of phosphodiesterase, especially PDE4-associated immune and inflammatory diseases, such as psoriasis and arthritis. (I)

Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst

Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly enantioselective manner. Various substitution patterns on the indole ring are well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water is essential, and its possible role is discussed.

A substituted indole -3 - acetic acid synthesis method (by machine translation)

The present invention provides a substituted indole - 3 - acetic acid synthesis method, comprises the following steps: (1) in order to replace the indole as the starting material, with the acylation reagent under the action of catalyst through the tutor - acylation to obtain the 1, 3 - diacetyl substituted indole; (2) intermediate 1, 3 - diacetyl substituted indole does not need refining, directly with the morpholine and sulfur by the Willgerodt - Kindler rearrangement reaction, the inorganic under the catalysis of alkali hydrolysis, acidified to obtain substituted indole - 3 - acetic acid. (by machine translation)

Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade

An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products.

Compounds exhibiting thrombopoietin-like activities

The compounds of the invention are compounds represented by the following general formula (1): wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo group, R1 represents one selected from the group consisting of optionally substituted aryl groups and optionally substituted heteroaryl groups, R2 represents one selected from the group consisting of a hydrogen atom and alkyl groups, W1 represents an amino acid residue, A represents one selected from the group consisting of a carbonyl group and a sulfonyl group, X1 represents one selected from the group consisting of optionally substituted alkylene groups and optionally substituted alkenylene groups, and p represents 0 or 1; and their pharmacologically acceptable salts, which exhibit thrombopoietin-like activity.

Halogenated indole-3-acetic acids as oxidatively activated prodrugs with potential for targeted cancer therapy

Substituted indole-3-acetic acid (IAA) derivatives, plant auxins with potential for use as prodrugs in enzyme-prodrug directed cancer therapies, were oxidised with horseradish peroxidase (HRP) and toxicity against V79 Chinese hamster lung fibroblasts was determined. Rate constants for oxidation by HRP compound I were also measured. Halogenated IAAs were found to be the most cytotoxic, with typical surviving fractions of -3 after incubation for 2 h with 100 μM prodrug and HRP.

A convenient method for the synthesis of indole-3-acetic acids

Starting from the corresponding indoles, indole-3-acetic acids were synthesized through indole-3-glyoxylic acids, followed by hydrazone formation with p-toluenesulfonhydrazide, then reduction of the hydrazones with sodium borohydride.