191215-96-0Relevant articles and documents
Solid phase synthesis of fused bicyclic amino acid derivatives via intramolecular Pauson-Khand cyclization: Versatile scaffolds for combinatorial chemistry
Bolton, Gary L.,Hodges, John C.,Rubin, J. Ronald
, p. 6611 - 6634 (1997)
Solution and solid phase synthetic methods leading to the rapid, stereocontrolled construction of highly functionalized fused bicyclic amino acid derivatives have been developed. The key step involves a unique application of the intramolecular Pauson-Khand cyclization for the construction of hexahydro-1H-[2]pyrindinone ring systems. Further modifications which demonstrate the potential for combinatorial library generation are also disclosed.