Solid phase synthesis of fused bicyclic amino acid derivatives via intramolecular Pauson-Khand cyclization: Versatile scaffolds for combinatorial chemistry

Article abstract of DOI:10.1016/S0040-4020(97)00220-2

Solution and solid phase synthetic methods leading to the rapid, stereocontrolled construction of highly functionalized fused bicyclic amino acid derivatives have been developed. The key step involves a unique application of the intramolecular Pauson-Khand cyclization for the construction of hexahydro-1H-[2]pyrindinone ring systems. Further modifications which demonstrate the potential for combinatorial library generation are also disclosed.