191217-37-5Relevant academic research and scientific papers
The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels
Burgess, Laurence E.,Koch, Kevin,Cooper, Kelvin,Biggers, Michael S.,Ramchandani, Mukesh,Smitrovich, Jacqueline H.,Gilbert, Eric J.,Bruns, Matthew J.,Mather, Robert J.,Donovan, Carol B.,Hanson, Douglas C.
, p. 1047 - 1052 (1997)
UK-78,282 was identified in a human T cell 86Rb efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective blocker of human T cell voltage-gated K+ channels and to inhibit T cell activation. The SAR around UK-78,282 and a general pharmacophore hypothesis are presented in this communication.
