Bioorganic and Medicinal Chemistry Letters p. 1047 - 1052 (1997)
Update date:2022-08-03
Topics:
Burgess, Laurence E.
Koch, Kevin
Cooper, Kelvin
Biggers, Michael S.
Ramchandani, Mukesh
Smitrovich, Jacqueline H.
Gilbert, Eric J.
Bruns, Matthew J.
Mather, Robert J.
Donovan, Carol B.
Hanson, Douglas C.
UK-78,282 was identified in a human T cell 86Rb efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective blocker of human T cell voltage-gated K+ channels and to inhibit T cell activation. The SAR around UK-78,282 and a general pharmacophore hypothesis are presented in this communication.
View MoreHangzhou Deli Chemical Co.,Ltd.
website:http://www.dlchemical.com
Contact:86 571 28006267
Address:Tangxi Industrial Area, Yuhang District, Hangzhou
Contact:+86-021-6989-5597
Address:No.80 Yichuan Rd., Putuo District,Shanghai,P.R.China
Shenzhen ZheYi Chemicals Co.,LTD(Shanghai Branch)
Contact:+86-21-54159691
Address:Room1002,Building No.2, Lane 98 Bixiu Road,Minhang District, Shanghai,China 201100
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd
Contact:028-85317716
Address:Tianfu Life Science Park, No. 88 South Keyuan Road, Gaoxin District, Chengdu City, Sichuan Province, PRC.
Rizhao Lanxing Chemical Indusrial Co.,Ltd
Contact:86-633-2616708
Address:NO.15 West road Shenglan, Lanshan district, Rizhao City
Doi:10.1016/j.tetlet.2009.09.049
(2009)Doi:10.1021/ja065935f
(2006)Doi:10.1021/jo00327a022
(1981)Doi:10.1021/ja00395a082
(1981)Doi:10.1016/S0022-328X(00)85754-X
(1981)Doi:10.1016/j.tet.2006.09.034
(2006)
