Bioorganic and Medicinal Chemistry Letters p. 1047 - 1052 (1997)
Update date:2022-08-03
Topics:
Burgess, Laurence E.
Koch, Kevin
Cooper, Kelvin
Biggers, Michael S.
Ramchandani, Mukesh
Smitrovich, Jacqueline H.
Gilbert, Eric J.
Bruns, Matthew J.
Mather, Robert J.
Donovan, Carol B.
Hanson, Douglas C.
UK-78,282 was identified in a human T cell 86Rb efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective blocker of human T cell voltage-gated K+ channels and to inhibit T cell activation. The SAR around UK-78,282 and a general pharmacophore hypothesis are presented in this communication.
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