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191217-81-9 Usage


Pramipexole, also known as Pramipexole Dihydrochloride, is a non-ergot dopamine agonist that is widely used for the treatment of various medical conditions. It is a white or almost white crystalline powder and is available as a hydrate, specifically the monohydrate of the dihydrochloride salt of pramipexole.


Used in Pharmaceutical Industry:
Pramipexole is used as a pharmaceutical secondary standard for various analytical applications. It is suitable for use in pharma release testing, pharma method development for qualitative and quantitative analyses, and other calibration requirements.
Used in Parkinson's Disease Treatment:
Pramipexole is used as an antiparkinsonian agent for the treatment of early and advanced Parkinson's disease (PD). It helps in managing the symptoms and improving the quality of life for patients with PD.
Used in Restless Legs Syndrome Treatment:
Pramipexole is used as a treatment for restless legs syndrome, a neurological disorder characterized by an uncontrollable urge to move the legs, often accompanied by uncomfortable sensations.
Used in Antidepressant Applications:
Pramipexole is used as an antidepressant, helping to alleviate symptoms of depression by modulating the levels of dopamine in the brain.
Used in Antipsychotic Applications:
Pramipexole is used as an antischizophrenic agent, assisting in the management of schizophrenia symptoms by targeting dopamine receptors in the brain.
Used in Dopamine Agonist Applications:
Pramipexole functions as a dopamine agonist, meaning it mimics the effects of dopamine in the body, which can be beneficial for various medical conditions related to dopamine imbalances.

Clinical Use

Parkinson’s disease Symptomatic treatment of restless legs

Drug interactions

Potentially hazardous interactions with other drugs Avoid concomitant use with antipsychotics.


Pramipexole undergoes <10% metabolism to inactive metabolites. More than 90% of a dose is excreted via renal tubular secretion unchanged into the urine.

Check Digit Verification of cas no

The CAS Registry Mumber 191217-81-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,2,1 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 191217-81:
129 % 10 = 9
So 191217-81-9 is a valid CAS Registry Number.

191217-81-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (P2073)  Pramipexole Dihydrochloride Monohydrate  >98.0%(HPLC)(N)

  • 191217-81-9

  • 100mg

  • 990.00CNY

  • Detail
  • TCI America

  • (P2073)  Pramipexole Dihydrochloride Monohydrate  >98.0%(HPLC)(N)

  • 191217-81-9

  • 1g

  • 5,190.00CNY

  • Detail
  • Sigma-Aldrich

  • (PHR1598)  Pramipexole Dihydrochloride  pharmaceutical secondary standard; traceable to USP, PhEur

  • 191217-81-9

  • PHR1598-500MG

  • 791.15CNY

  • Detail
  • Sigma-Aldrich

  • (Y0001266)  Pramipexole dihydrochloride monohydrate  European Pharmacopoeia (EP) Reference Standard

  • 191217-81-9

  • Y0001266

  • 1,880.19CNY

  • Detail
  • Sigma-Aldrich

  • (Y0001187)  Pramipexole for system suitability  European Pharmacopoeia (EP) Reference Standard

  • 191217-81-9

  • Y0001187

  • 1,880.19CNY

  • Detail
  • USP

  • (1553859)  Pramipexole dihydrochloride monohydrate  United States Pharmacopeia (USP) Reference Standard

  • 191217-81-9

  • 1553859-200MG

  • 4,662.45CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017


1.1 GHS Product identifier

Product name pramipexole hydrochloride

1.2 Other means of identification

Product number -
Other names (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole Dihydrochloride Monohydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:191217-81-9 SDS

191217-81-9Downstream Products

191217-81-9Relevant articles and documents

Preparation method of high-purity pramipexole dihydrochloride


Paragraph 0027; 0030-0045, (2021/01/30)

The invention provides a preparation method of high-purity pramipexole dihydrochloride, which comprises the following steps: (a) by using (S)-2-amino- 6-propionamido 4, 5, 6, 7-tetrahydrobenzothiazoleas a raw material and tetrahydrofuran as a solvent, reacting in the presence of a reducing agent, and adding diluted hydrochloric acid to terminate the reaction after the reaction is completed; (b) adding a sodium hydroxide solution to adjust the pH value, adding an extraction agent for extraction, adding an alcohol reagent, dropwise adding concentrated hydrochloric acid for salifying, cooling for crystallization, filtering and drying to obtain pramipexole dihydrochloride monohydrate; and (c) refining the pramipexole dihydrochloride monohydrate obtained in the step (b) through a ternary system of water, an alcohol reagent and an ester reagent, filtering and drying to obtain a pramipexole dihydrochloride finished product. The novel synthetic method of pramipexole dihydrochloride is simplein reaction steps, high in safety, high in yield, stable in water content and suitable for industrial production, and the purity of pramipexole dihydrochloride reaches 99.95% or above. The pramipexoledihydrochloride has stable water content and is suitable for industrial production.



Page/Page column 12, (2008/12/07)

The invention relates to processes for the preparation of pramipexole or pharmaceutically acceptable salts thereof. More particularly, it relates to a process for the preparation of pramipexole dihydrochloride monohydrate. The invention also relates to a novel compound, 2-bromo-4-aminocyclohexanone and processes for its preparation. The 2- bromo-4-aminocyclohexanone is a useful intermediate in the preparation of pramipexole or salts thereof. The invention further relates to a single step process for the preparation of 2,6-diamino-4,5,6,7-tetrahydrobenzathiazole, an intermediate useful in the preparation of pramipexole or salts thereof.

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