19127-15-2Relevant academic research and scientific papers
Anti-inflammatory triterpenoid saponins from the stem bark of Kalopanax pictus
Quang, Tran H.,Ngan, Nguyen T.T.,Minh, Chau V.,Kiem, Phan V.,Nhiem, Nguyen X.,Tai, Bui H.,Thao, Nguyen P.,Tung, Nguyen H.,Song, Seok B.,Kim, Young H.
experimental part, p. 1908 - 1915 (2011/11/11)
Five new compounds, 16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid (1), 4,23,29-trihydroxy-3,4-seco-olean-12-en-3-oate-28-oic acid (2), 3-2-en-28-oic acid 28-O-β-d-glucopyranoside (3), 3-O-[2,3-di-O-acetyl-α-l- arabinopyranosyl]hederagenin 28-O-α-L-rhamnopyranosyl-(→4)-β-d- glucopyranosyl-(→6)-β-d-glucopyranoside (4), and 3-O-[3,4-di-O-acetyl- α-l-arabinopyranosyl]hederagenin 28-O-α-L-rhamnopyranosyl-(→4)- β-d-glucopyranosyl-(→6)-β-d-glucopyranoside (5), as well as 10 known compounds (6-15), were isolated from the stem bark of Kalopanax pictus. Compounds 1-5 and 7-14 inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells in a dose-dependent manner, with IC50 values ranging from 0.6to 16.4 μM. Furthermore, the transcriptional inhibitory function of these compounds was confirmed on the basis of decreases in COX-2 and iNOS gene expression in HepG2 cells. The structure-activity relationship of the compounds with respect to anti-inflammatory activity is also discussed.
