18156-74-6 Usage
Chemical Properties
Colorless transparent liquid
Physical properties
bp 93–94 °C/14 mmHg; fp 5 °C; d 0.956 g cm?3.
Uses
Different sources of media describe the Uses of 18156-74-6 differently. You can refer to the following data:
1. N-(trimethylsilyl) imidazole (TMSim) is quite reactive with hydroxyl groups in a variety of analytes including a variety of lipids.As with other derivatization reactions,microwave heating can greatly improve process efficiency.
2. N-(Trimethylsilyl)imidazole is a silylating agent for alcohols and 1,3-dicarbonyl compounds; reaction with esters to give imidazolides; preparation of
O-trimethylsilyl monothioacetals; aromatization of the A-ring of steroids. It participates in the reactions of Hydroxyl Silylation Reactions, Silyl Aminal Formation Reactions, Nitrogen Silylation Reactions, Acyl Imidazole Formation, Michael Addition Reactions, Substitution Reactions, Phosphoroimidazolidate Formation, and other uses.
3. A general silylating agent, particularly for alcohols. An intermediate for the synthesis of imidazole derivatives.
4. Silylating reagent for the protection of hydroxyl groups in the presence of amine functionalities.1
Definition
ChEBI: A member of the class of imidazoles in which the hydrogen at position 1 is replaced by a trimethylsilyl group. N-trimethylsilylimidazole is a derivatisation agent used in gas chromatography/mass spectrometry applications.
General Description
1-(Trimethylsilyl)imidazole (TMSIM) has high silyl donor ability. It does not react with amino groups and also does not help in formation of enol-ether on unprotected ketone groups. It is useful as a silylating agent for ecdysones, norepinephrine, dopamine, steroids, sugars, sugar phosphates and ketose isomers.
Check Digit Verification of cas no
The CAS Registry Mumber 18156-74-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,1,5 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 18156-74:
(7*1)+(6*8)+(5*1)+(4*5)+(3*6)+(2*7)+(1*4)=116
116 % 10 = 6
So 18156-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H12N2Si/c1-9(2,3)8-5-4-7-6-8/h4-6H,1-3H3
18156-74-6Relevant articles and documents
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Pullukat,Urry
, p. 1953 (1967)
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Synthesis and structure of silyl-substituted imidazol-2-ylidenes and their precursors
Komarova,Larina,Abramova,Dolgushin
, p. 1089 - 1092 (2007)
Previously unknown heterocyclic carbenes and their precursors containing a silicon atom in the side chain were prepared. Their structures were studied by multinuclear 1H, 13C, 15N, and 29Si NMR spectroscopy.
Chitosan–silica sulfate nanohybrid: a highly efficient and green heterogeneous nanocatalyst for the regioselective synthesis of N-alkyl purine, pyrimidine and related N-heterocycles via presilylated method
Behrouz, Somayeh,Soltani Rad, Mohammad Navid,Piltan, Mohammad Amin
, p. 113 - 124 (2019/07/30)
Abstract: The presilylation of purine and pyrimidine nucleobases as well as other related N-heterocycles with HMDS utilizing chitosan–silica sulfate nanohybrid (CSSNH) is described. CSSNH is proved to be a useful, highly efficient and eco-friendly heterogeneous nanohybrid catalyst for silylation of nucleobases. The presilylated nucleobases then underwent the reaction with different sources of carbon electrophiles to afford the desired N-alkyl-substituted derivatives in good-to-excellent yields. CSSNH exhibits several advantageous involving ease of handling and preparation, low cost, reusability and environmental benignity. These unique properties render the CSSNH to be an ideal candidate for use in green industrial processes. Graphic abstract: [Figure not available: see fulltext.].
Desulfurization of hydrocarbons by ionic liquids and preparation of ionic liquids
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Page/Page column, (2014/09/16)
The present invention relates to an improved desulfurization process using an ionic liquid compound of general formula C+A?, where C+ represents an organic cation such as alkyl-pyridinium, di-alkyl imidazolium and tri-alkyl imidazolium; and A? is an anion of halides of iron (III), such as, for example, FeCl4?. The desulfurization process is also improved when producing the ionic liquid compound by heating the reactants using microwave energy. The ionic liquids can be used to desulfurize hydrocarbon mixtures by a liquid-liquid extraction.