191276-34-3

Upstream product

• 318464-25-4 (4S,5R)-N-boc-2-(2,4-dimethoxy-phenyl)-4-isobutyl-1-oxazolidine-5-carboxylic acid methyl ester 
• 675584-92-6 N-Boc-N,O-(2,4-dimethoxybenzylidene)-β-isobutylisoserine sodium salt 

Downstream Products

• 675584-53-9 C₅₈H₈₀N₄O₁₇Si 
• 675584-58-4 C₅₉H₈₀N₂O₁₈Si 
• 675584-87-9 C₆₀H₈₁NO₂₀Si 
• 934686-96-1 2-(2,4-dimethoxy-phenyl)-4-isobutyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-(7,9,10-triacetoxy-5-hydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0^3,8]pentadec-11-en-13-yl) ester 
• 13698-16-3 ethyl N,N-dichlorocarbamate 
• 318464-46-9 C₅₉H₇₉NO₁₉Si 
• 941602-61-5 (7-trichloroacetyl)-13-(N-Boc-2-(2,4-dimethoxyphenyl)-4-isobutyl-5-oxazolidinyl)-14-β-hydroxybaccatin-1,14-carbonate 
• 943239-57-4 C₅₅H₇₁NO₁₇ 
• 1036915-57-7 C₅₄H₆₃Cl₆NO₁₈ 

Relevant academic research and scientific papers

PROCESSES FOR TAXANE DERIVATIVES AND INTERMEDIATES USEFUL THEREIN

The application provides a process for the preparation of taxane derivatives and intermediates useful in such processes.

TAXANE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The invention discloses an oxazolidine intermediate for the synthesis of 14- beta -hydroxy-1,14-carbonate-baccatines bearing a 13-isoserine substituent, and a process for the preparation thereof.

TAXANE DERIVATIVES FUNCTIONALIZED AT THE 14- POSITION AND A PROCESS FOR THE PREPARATION THEREOF

A general process for the functionalization at the 14- position of 13-ketobaccatin derivatives of formula I to give derivatives of formula II wherein the substituents are as defined in the disclosure. The conversion of compounds of formula II in compounds of formula III, wherein the substituents are as defined in the disclosure, is also described.