318464-25-4

Upstream product

• 67-56-1 methanol 
• 675584-92-6 N-Boc-N,O-(2,4-dimethoxybenzylidene)-β-isobutylisoserine sodium salt 
• 942485-86-1 C₂₁H₃₀ClNO₆ 
• 91352-76-0 2,4-dimethoxybenzaldehyde dimethylacetal 

Downstream Products

• 1269040-39-2 C₄₆H₅₄⁽²⁾H₉NO₁₅ 
• 1269040-51-8 C₂₂H₂₄⁽²⁾H₉NO₇ 
• 1269040-52-9 C₂₁H₂₁⁽²⁾H₉NO₇^(1-)*Na⁽¹⁺⁾ 
• 1269040-53-0 C₅₅H₆₂⁽²⁾H₉NO₁₇ 
• 191276-34-3 (4S,5R)-N-(tert-butoxycarbonyl)-2-(2,4-dimethoxyphenyl)-4-iso-butyl-5-oxazolidinecarboxylic acid 

Relevant academic research and scientific papers

TAXANE ANALOGUES, THEIR USE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION

The present invention relates to novel taxane analogues, processes of making the novel taxane analogues, compositions containing the novel taxane analogues, and their use in treating cancer and neurodegenerative disorders. In some embodiments, the taxane analogues are represented by the generic structure of formula (I) : wherein R1, R2,R3 and A are defined herein; and esters especially pro-drugs thereof wherein one or more of the hydroxy! groups is esterified to form an in-vivo hydrolysable ester group; or pharmaceutically acceptable salts thereof.

PROCESSES FOR TAXANE DERIVATIVES AND INTERMEDIATES USEFUL THEREIN

The application provides a process for the preparation of taxane derivatives and intermediates useful in such processes.

TAXANE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The invention discloses an oxazolidine intermediate for the synthesis of 14- beta -hydroxy-1,14-carbonate-baccatines bearing a 13-isoserine substituent, and a process for the preparation thereof.