191277-97-1Relevant articles and documents
Synthesis of all four isomers of (E)-4,5-dihydroxydec-2-enal using osmium-catalysed asymmetric dihydroxylation
Allevi, Pietro,Tarocco, Giorgio,Longo, Alessandra,Anastasia, Mario,Cajone, Francesco
, p. 1315 - 1325 (1997)
The enantioselective synthesis of the four possible isomers of (E)-4,5-dihydroxydec-2-enal, a cytotoxic product formed in peroxidised liver microsomal lipids, is accomplished via a Sharpless AD reaction alone or associated as appropriate with a regioselective epimerisation of one of the introduced hydroxy groups.