191282-48-1

Basic information

• Product Name: C75
• Synonyms: TETRAHYDRO-4-METHYLENE-2-OCTYL-5-OXO-3-FURANCARBOXYLIC ACID;C75;4-METHYLENE-2-OCTYL-5-OXOTETRAHYDROFURAN-3-CARBOXYLIC ACID;trans-C 75 (trans-4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid);(2R,3S)-4-METHYLIDENE-5-OXO-2-N-OCTYL-OXOLANE-3-CARBOXYLIC ACID;(2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylicacid;(2R,3S)-rel-Tetrahydro-4-Methylene-2-octyl-5-oxo-3-furancarboxylic Acid;trans-Tetrahydro-4-Methylene-2-octyl-5-oxo-3-furancarboxylic Acid
• CAS NO: 191282-48-1
• Molecular Formula: C14H22O4
• Molecular Weight: 254.32
• Product Categories: pharmacetical
• Mol File: 191282-48-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 432.1 ºC at 760 mmHg
• Flash Point: 159.2ºC
• Appearance: off-white/solid
• Density: 1.08 g/cm³c
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: 2-8°C
• Solubility: DMSO: 18 mg/mL
• PKA: 3.08±0.40(Predicted)
• CAS DataBase Reference: C75(CAS DataBase Reference)
• NIST Chemistry Reference: C75(191282-48-1)
• EPA Substance Registry System: C75(191282-48-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 191282-48-1(Hazardous Substances Data)

Usage

Chemical Description

C75 is another compound whose in vitro FAS inhibitory activity is being studied.

InChI:InChI=1/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1

Upstream product

• 1234694-21-3 methyl (2S,3R)-4-methylene-5-oxo-2-octyltetrahydrofuran-3-carboxylate 
• 7338-27-4 4-methoxy-2-methylene-4-oxobutanoic acid 
• 124-19-6 nonan-1-al 
• 60427-77-2 4-((4-methoxybenzyl)oxy)-2-methylene-4-oxobutanoic acid 
• 58588-90-2 α-bromomethyl-γ-butene lactone 
• 547-65-9 α-methylene-γ-butyrolactone 

Relevant articles and documents

Total syntheses of paraconic acids and 1,10-seco-guaianolides via a barbier allylation/translactonization cascade of 3-(Bromomethyl)-2(5H)-furanone

A palladium-catalyzed Barbier allylation/translactonization cascade reaction was established for the rapid construction of β,γdisubstituted α-exo-methylene-γ-butyrolactone, an important motif in sesquiterpenes. Dimethyl zinc played significant roles in bo

The first kinetic enzymatic resolution of methyl ester of C75

Enantioselective hydrolysis of methyl ester of (±)-C75 was successfully accomplished by means of Acylase I from Aspergillus to afford (2,R,3S)-(+)-C75 with 96% e.e. The unreacted methyl ester was recovered with >99% e.e. This latter compound was either chemically or enzymatically hydrolyzed to furnish (2S,3,R)-(-)-C75 with >99% e.e.