191330-56-0Relevant articles and documents
Ezetimibe intermediate and synthesis method thereof
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, (2018/04/02)
The invention provides a new ezetimibe intermediate and a preparation method thereof. The preparation method comprises: (1) converting 4-(4-fluoro-benzoyl)-butyric acid into 4-[2-(4-fluoro-phenyl)-[1,3]dithiolan-2-yl]-butyric acid through a un-separated intermediate compound; and (2) carrying out acylation on chiral oxazolidone by using the 4-[2-(4-fluoro-phenyl)-[1,3]dithiolan-2-yl]-butyric acid to obtain the oxazolidone derivative VI. According to the present invention, the route is simple, cheap and efficient, and the obtained product has advantages of less impurity, high purity, and high yield.
Ezetimibe intermediate compound
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Paragraph 0075; 0076; 0087; 0098; 0109; 0120, (2018/04/02)
The invention provides a new ezetimibe intermediate and a preparation method thereof, wherein the ezetimibe intermediate is prepared from 4-(4-fluoro-benzoyl)-butyric acid in one step. According to the present invention, the route is simple, cheap and efficient; and in order to well protect the functional group, the route uses the protection group capable of being selectively removed, and the obtained product has advantages of less impurity, high purity, and high yield.
Preparation method of ezetimibe and key intermediates thereof of lipid-lowering drugs
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, (2017/09/13)
The invention relates to a preparation method of ezetimibe and key intermediates thereof of lipid-lowering drugs. The preparation method is applicable to industrial production.