191349-60-7Relevant articles and documents
Chemistry development of a convergent route to trecetilide hemi-fumarate
Mackey, Sonja S.,Wu, Haifeng,Matison, Michael E.,Goble, Michael
, p. 174 - 178 (2005)
A novel, efficient, stereoselective synthetic route for N-(4-{4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-(S)-hydroxybutyl}-phenyl) methanesulfonamide hemi-fumaric acid salt (trecetilide hemi-fumarate, Figure 1) has been developed. The process features a convergent approach, which assembles two key intermediates in the last step to form the final molecule, which is then isolated by pH-controlled extraction. The new route offers significant yield and purity advantages over the previous route. However, the solvent volume and cycle time were not fully optimized due to the termination of the project.