19135-40-1

Basic information

• Product Name: bis(4-chlorobenzyl)tin dichloride
• Synonyms: bis(4-chlorobenzyl)tin dichloride
• CAS NO: 19135-40-1
• Molecular Formula: C14H12 Cl4 Sn
• Molecular Weight: 0
• Mol File: 19135-40-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 446°C at 760 mmHg
• Flash Point: 223.5°C
• Appearance: /
• Vapor Pressure: 9.95E-08mmHg at 25°C
• CAS DataBase Reference: bis(4-chlorobenzyl)tin dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: bis(4-chlorobenzyl)tin dichloride(19135-40-1)
• EPA Substance Registry System: bis(4-chlorobenzyl)tin dichloride(19135-40-1)

Safety Data

• Hazardous Substances Data: 19135-40-1(Hazardous Substances Data)

Usage

InChI:InChI=1/2C7H6Cl.2ClH.Sn/c2*1-6-2-4-7(8)5-3-6;;;/h2*2-5H,1H2;2*1H;/q;;;;+2/p-2/rC14H12Cl4Sn/c15-13-5-1-11(2-6-13)9-19(17,18)10-12-3-7-14(16)8-4-12/h1-8H,9-10H2

Upstream product

• 7440-31-5 tin 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Downstream Products

• 1093074-71-5 (p-chlorobenzyl)2Sn(2-phenylethyl dithiocarbamate)2 
• 1147090-75-2 (para-chlorobenzyl)2SnCl₂(benzaldehyde 2-phenylethyl N-thiohydrazone) 

Relevant articles and documents

Synthesis, structural characterization, cytotoxicity and encapsulation studies of N,N′-(1, 2-dicyano-1,2-vinylene)-bis(4-hydroxysalicylideneaminato) di(p-chlorobenzyl)tin as potential anticancer drug

Two new diorganotin(IV) complexes with the general formula (RC7H6)2Sn(L) (where RC7H6 = p-ClBn, C1; and p-FBn, C2) were prepared based on the reaction of 2,3-bis(4-hydroxysalicylidene-amino)-maleic ni

Diversity of complexes based on p-nitrobenzoylhydrazide, benzoylformic acid and diorganotin halides or oxides self-assemble: Cytotoxicity, the induction of apoptosis in cancer cells and DNA-binding properties

Eight organotin(IV) complexes (C1-C8) have been synthesized and characterized by elemental analysis, fourier transform infrared spectroscopy (FT-IR), multinuclear nuclear magnetic resonance (1H, 13C and 119Sn NMR), high resolution mass spectroscopy (HRMS) and single crystal X-ray structural analysis. Crystallographic data show that C1 was a tetranuclear 16-membered macrocycle complex, C2-C4 and C7 were centrosymmetric dimer distannoxane and there was a Sn2O2 four-membered ring in the middle of the molecule, respectively, C5 and C6 are monoorganotin complexes due to the dehydroalkylation effect during the reaction, while C8 forms a one-dimensional chain structure. The cytotoxicity of all complexes were tested by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assays against three human tumor cell lines NCI-H460, MCF-7 and HepG2. The dibutyltin complex C2 has been shown to be more potent antitumor agents than other complexes and carboplatin. Cell apoptosis study of C2 with the high activity on HepG2 and MCF-7 cancer cell lines was investigated by flow cytometry, it was shown that the antitumor activity of C2 was related to apoptosis, but it has different cell cycle arrest characteristics from platinum compounds, and the proliferation was inhibited by blocking cells in S phase. The DNA binding activity of the C2 was studied by UV–visible absorption spectrometry, fluorescence competitive, viscosity measurements and gel electrophoresis, results shown C2 can be well embedded in the double helix of DNA and cleave DNA.