1914-00-7

Basic information

• Product Name: 1-Butyl-3-methyl-1H-indole
• Synonyms: 1-Butyl-3-methyl-1H-indole
• CAS NO: 1914-00-7
• Molecular Formula: C₁₃H₁₇N
• Molecular Weight: 0
• Mol File: 1914-00-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Butyl-3-methyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butyl-3-methyl-1H-indole(1914-00-7)
• EPA Substance Registry System: 1-Butyl-3-methyl-1H-indole(1914-00-7)

Safety Data

• Hazardous Substances Data: 1914-00-7(Hazardous Substances Data)

Usage

Type of compound

Indole
Indoles are heterocyclic aromatic organic compounds, and 1-Butyl-3-methyl-1H-indole is a derivative of this type of compound.

Molecular structure

Butyl and methyl group attachments
The compound features a butyl group attached to one carbon atom and a methyl group attached to another carbon atom in the molecule, making it distinct from other indole derivatives.

Usage

Synthesis of pharmaceuticals and agrochemicals
1-Butyl-3-methyl-1H-indole is commonly used as an intermediate or building block in the production of various pharmaceutical and agrochemical products.

Biological activities

Antimicrobial and antifungal properties
Research has shown that this compound exhibits potential antimicrobial and antifungal activities, suggesting possible applications in the treatment of infections or the control of fungal growth.

Versatility

Range of potential applications
Due to its unique structure and properties, 1-Butyl-3-methyl-1H-indole has a broad range of potential applications across different industries, including healthcare, agriculture, and chemical manufacturing.

Upstream product

• 343777-43-5 C₁₃H₂₀N₂ 
• 61715-75-1 N-butyl-N-phenylhydrazine 
• 109-65-9 1-bromo-butane 
• 83-34-1 3-Methylindole 
• 112817-85-3 1-butyl-3-methylindoline-2-thione 
• 63212-32-8 1-ethyl-2-isocyanobenzene 
• 5311-88-6 propanal N-phenylhydrazone 
• 10468-64-1 o-tolyl isocyanide 

Downstream Products

• 1262588-69-1 1-butyl-3-methyl-2-m-tolylindole 
• 1262588-70-4 1-butyl-2-(3,5-dimethylphenyl)-3-methylindole 
• 1262588-60-2 1-butyl-2-(3-methoxyphenyl)-3-methylindole 
• 1262588-71-5 1-butyl-2-(3,4-dimethylphenyl)-3-methylindole 

Relevant articles and documents

Palladium-catalysed dehydrogenative generation of imines from amines. A nature-inspired route to indoles via cross-couplings of amines with arylhydrazines

H-substituted imines are elusive compounds formed when aldehydes or ketones are mixed with ammonia. However, this class of molecules can be prepared through selective removal of a hydrogen molecule from a primary amine using a transition metal catalyst. This biomimetic transformation, previously employed for the N-alkylation of anilines, is applied here to a domino preparation of differently substituted indoles from aliphatic primary amines and arylhydrazines. Several different linear and branched aliphatic primary amines are oxidized with reusable palladium on charcoal to the corresponding primary imines entrapped as arylhydrazones that can be isolated as such. Arylhydrazones can be further converted into N-alkylindole derivatives via an acid-mediated indolisation reaction. The one-pot domino hydrogen transfer Fischer indole synthesis under heterogeneous catalysis is also possible, giving access to diverse substituted indoles, including NH indoles obtained after deprotection of the corresponding benzyl compounds. The truly heterogeneous nature of the catalyst was demonstrated by recycling the catalyst in the same reaction, and in other palladium-catalysed transformations.

Photodesulfurization of indoline-2-thiones: A facile synthesis of indoles

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INDOLE DERIVATIVES. 121. CONVENIENT METHOD FOR THE PREPARATION OF N-ALKYLINDOLES

A new method was developed for the synthesis of N-alkylindoles from phenylhydrazones of aldehydes and ketones that makes it possible to obtain diverse N-alkylindoles under mild conditions.